Self-administered COgnitive Personalized Training in Early Psychosis

Recruiting now · Not applicable

Conditions studied: First Episode Psychosis (FEP)

In brief

The overall objective of SCOPe is to improve early intervention in psychosis by providing an innovative eHealth tool that will enable personalized cognitive training, adapted to the individual's cognitive abilities. Cognitive remediation improves quality of life and functional outcome in patients with chronic psychosis. It would even be more efficacious in the early phase of psychosis by tackling the negative impact of psychosis on education achievement and employment. However, cognitive dysfunctions are often overlooked in FEP and cognitive remediation is not always accessible. New technologies can provide us with youth-friendly, non-stigmatizing tools, such as self administered, training applications so that all first-line clinical settings or professionals, and in fine all patients, can have access, wherever they live, to personalized cognitive training focusing on impaired functions. Early psychosis can be associated with inflammation, metabolic deficiency, as well as early structural brain anomalies that reflect brain plasticity abilities and could influence the prognosis and response to cognitive training. Our background hypothesis is that promoting neuroplasticity by cognitive training could attenuate or reverse early cognitive deficits and improve the overall functional outcome in young patients experiencing FEP and that this effect is modulated by individual brain plasticity abilities.

Key facts

Study ID

NCT06634446

Run by

Centre Hospitalier St Anne

People needed

240

Starts

2021-10-26

Expected to finish

2027-12-30

Last updated by the study team

2024-10-10

Who can join

Age: 16 and older, up to 35. Sex: any. Healthy volunteers: accepted.

You may qualify if…

• Adolescent and young adults, both genders, aged 16 to 35,
• Seeking help in one of the recruiting centers,
• Newly diagnosed as experiencing an Episode of Psychosis (reaching criteria as described in the Comprehensive Assessment of at Risk Mental States (CAARMS) within the year
• Written informed consent signed (and from one legal guardian for minors).

You may not qualify if…

• Severe and unstabilized medical conditions,
• Insufficient level in reading and/or French language,
• Absence of medical insurance,
• Participation in another intervention trial,
• Enforced hospitalization (ASPDT, ASPPI, ASPRE),
• Intellectuel Deficiency (IQ\<70), and / or sensorimotor deficits incompatible with the cognitive training,

Where it is running

• Groupe Hospitalier Universitaire Paris - Psychiatrie et Neurosciences, (GHU Paris) — Paris, France (enrolling)

Full record on ClinicalTrials.gov

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