A Phase 2 Clinical Study of ABSK061 and ABSK043

Recruiting now · Phase 2

Conditions studied: HER2-Gastric/Gastroesophageal Junction Cancer, Urothelial Carcinoma, Non-Small Cell Lung Cancer, Solid Tumors

In brief

The purpose of this study is to evaluate the anti-tumor activity of ABSK061 + ABSK043 in terms of overall response rate (ORR) in in Patients with Metastatic/Unresectable Solid Tumors with FGFR2/3 Alterations

Key facts

Study ID

NCT06632262

Run by

Abbisko Therapeutics Co, Ltd

People needed

202

Starts

2024-11-13

Expected to finish

2030-06-30

Last updated by the study team

2024-11-19

Who can join

Age: 18 and older. Sex: any. Healthy volunteers: not accepted.

You may qualify if…

• Patients must have a measurable target lesion (per RECIST v1.1) (not applicable to expansion cohort 1) where:
• Dose Escalation: patients with histologically confirmed solid tumors who have progressed after standard of care, are unable to tolerate standard therapy, or have no standard of care currently available:
• Patients must have the a central laboratory or previous test report confirming FGFR2/3 gene activatingon alterations (including FGFR2/3 activating mutations, fusions/rearrangements, or FGFR2 amplifications) or overexpression in tumor tissue or blood based on central laboratory test or previous test reports.
• Expansion Phase:
• Cohort 1 (HER2-gastric/gastroesophageal junction cancer)
• Histologically or cytologically confirmed metastatic/unresectable gastric/gastroesophageal junction cancer, HER2 test negative
• The patient had FGFR2 amplification or overexpression in tumor tissue confirmed by a central laboratory test or a previous test report (previous test report only applied to FGFR2 amplification)
• Patients need to provide prior tumor tissue or willingness to undergo biopsy if no prior tumor tissue or insufficient quantity is required
• No prior (or up to one course of chemotherapy) systemic therapy for advanced gastric/gastroesophageal junction cancer, or disease progression more than 6 months after the end of the last prior adjuvant therapy
• Patients must have a measurable target lesion or evaluable non-target lesion (per RECIST v1.1)
• Cohort 2 (urothelial carcinoma)
• Histologically or cytologically confirmed metastatic/unresectable urothelial carcinoma with other histologic differentiation (including adenoid, squamous, or other types)
• Patients must have the prespecified a central laboratory or previous test report confirming the presence of a specific FGFR3 mutation or overexpression, FGFR2/3 fusion in tumor tissue or blood based on central laboratory test or previous test reports.
• No prior (or up to one course of chemotherapy) systemic therapy for advanced urothelial carcinoma, or disease progression more than 12 months after the end of the last prior adjuvant therapy, or disease progression or intolerable toxicity after at least one line of standard of care (per local standard of care or guidelines)
• Cohort 3 (non-small cell lung cancer)
• Histologically or cytologically confirmed metastatic/unresectable non-small cell lung cancer (NSCLC)
• Patients must have the prespecified a central laboratory or previous test report confirming the presence of a specific FGFR2/3 mutation, fusion, or overexpression in tumor tissue or blood based on central laboratory test or previous test reports.
• Disease progression or intolerable toxicity after at least one prior line of standard of care or targeted therapy for driver mutations (according to local standards of care or guidelines)
• Cohort 4 (Other Solid Tumors)
• Histologically or cytologically confirmed metastatic/unresectable other solid tumors
• Patients must have a central laboratory or previous test report confirmingthe FGFR2/3 gene activationng alterations (including FGFR2/3 activating mutations, fusions/rearrangements, or FGFR2 amplifications) or overexpression in tumor tissue or blood based on central laboratory test or previous test reports.
• Disease progression or intolerable toxicity after at least one prior line of standard therapy.

You may not qualify if…

• Previous treatment with an FGFR pathway inhibitor or a multi-kinase inhibitor designed to inhibit FGFR (consultation with the sponsor is recommended)
• Active or medical history of autoimmune diseases, including but not limited to myasthenia gravis, myositis, autoimmune hepatitis, systemic lupus erythematosus, rheumatoid arthritis, inflammatory bowel disease, vascular thrombosis associated with antiphospholipid syndrome, Wegener's granulomatosis, Sjögren's syndrome, Guillain-Barré syndrome, multiple sclerosis, vasculitis, or glomerulonephritis. (Patients with type 1 diabetes mellitus, hypothyroidism requiring hormone replacement therapy only, skin diseases that do not require systemic treatment (e.g., vitiligo, psoriasis, or alopecia) are allowed.Uncertain autoimmune-related status should be discussed with the sponsor).
• The patient had clinically symptomatic lung disease (e.g. interstitial pneumonia, pulmonary fibrosis, severe radiation pneumonitis, etc.) requiring systemic corticosteroid therapy within 6 months prior to enrollment.
• Known other malignancies that are in progression or require active treatment (except cured skin cancer, carcinoma in situ of the cervix, basal cell carcinoma, focal prostate cancer with a Gleason score of 6, focal prostate cancer with a Gleason score of 3 + 4 and treated for more than 6 months at screening).
• Time from the end of other prior anti-tumor therapy to the first dose of study drug: major surgery (palliative treatment for local lesions is allowed), in vitro and in vivo radiotherapy (> 30% bone marrow exposure) is less than 4 weeks; received immunotherapy or other antibody study drugs within 4 weeks prior to the start of study treatment; received chemotherapy (within 6 weeks of the start of study treatment with nitrosourea or mitomycin chemotherapy), endocrine therapy, and small molecule targeted therapy within 2 weeks or 5 half-lives, whichever is shorter.
• Patients who have not recovered to ≤ Grade 1 (CTCAE v5.0) from toxicities caused by prior chemotherapy, radiotherapy, and other anti-tumor therapies, including immunotherapy (except for alopecia as permitted by eligibility criteria or alopecia, vitiligo, stable hypothyroidism controlled by hormone replacement therapy, ≤ Grade 2 hearing loss, or ≤ Grade 2 peripheral neurotoxicity).
• History of ≥ Grade 3 immune-related adverse events with prior therapy.
• (Expansion Cohort 3 (non-small cell lung cancer)) Patients were previously identified with driver mutations (according to local diagnostic and therapeutic criteria or guidelines such as EGFR mutation, ALK rearrangement positive, KRAS G12C mutation positive, NTRK1/2/3 gene fusion positive, RET fusion positive, MET exon 14 skipping mutation, BRAF V600E mutation positive, ROS1 rearrangement positive) and did not receive targeted therapy.

Where it is running

• ZhongShan Hospital Fudan University — Shanghai, Shanghai Municipality, China (enrolling)
• The Affiliated Hospital of Guizhou Medical University — Guiyang, Guizhou, China
• The Fourth Hospital of Hebei Medical University — Shijiazhuang, Heibei, China
• Harbin Medical University Cancer Hospital — Harbin, Heilongjiang, China
• Henan Cancer Hospital — Zhengzhou, Henan, China
• Hunan Central Hospital — Changsha, Hunan, China
• Jiangxi Cance Hospital — Nanchang, Jiangxi, China
• Liaoning Cancer Hospital and Institute — Shenyang, Liaoning, China
• Cancer Hospital of Shandong First Medical University — Jinan, Shandong, China
• Xiangyang Central Hospital — Xiangyang, Sichuang, China
• Changzhi People's Hospital — Changzhi, China
• West China Hospital, Sichuan University — Chengdu, China
• The First Hospital of China Medical University — Hangzhou, China
• Zhejiang Provincial People'S Hospital — Hangzhou, China
• Tianjin Medical University Cancer Institute and Hospital — Tianjin, China
• Tongji Hospital affiliated to Tongji Medical College of Huazhong University of Science & Technology — Wuhan, China
• First Hospital of Shanxi Medical University — Xi'an, China
• Shanxi Cancer hospital (Shanxi Cancer institute) — Xi'an, China
• First Affiliated Hospital of Xiamen University — Xiamen, China
• Guizhou Provincial People'S Hospital — Guiyang, Guizhou, China
• The Affiliated Hospital of Xuzhou Medical University — Xuzhou, China

Full record on ClinicalTrials.gov

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