D3-Creatine and Skeletal Muscle in Older Adults

Recruiting now

Conditions studied: Aging, Muscle Loss

In brief

The age-related decline in muscle mass and strength are collectively referred to as sarcopenia. However, the tools currently employed to assess skeletal muscle mass (SMM) (e.g., Dual-energy Xray Absorptiometry; DXA) have substantial drawbacks, and it is known that DXA-lean soft tissue (LST) is generally not associated with health outcomes of interest. Thus, the investigators propose using a novel, non-invasive, stable isotope-labelled probe (Deuterium (D)-labelled creatine (D3-creatine; D3-Cr)) to measure skeletal muscle mass in a large cohort of older individuals. The development and employment of new methods to accurately quantify the biological substrate of sarcopenia, skeletal muscle, are critical for the measure to remain clinically relevant. The plan is to measure 350 persons from the recently established (M3) prospective cohort. There will be measurement of lean soft tissue LST and appendicular LST (aLST) using DXA and compared to D3-Cr-measured SMM (D3-Cr-SMM) at baseline, 12mo, and 24mo (2yr) of follow-up. Physical mobility will also be measured (using various instruments).

Key facts

Study ID: NCT06630949
Run by: McMaster University
People needed: 350
Starts: 2023-10-01
Expected to finish: 2027-06-30
Last updated by the study team: 2024-10-08

Who can join

Age: 60 and older. Sex: any. Healthy volunteers: accepted.

You may qualify if…

Participants will be considered eligible for this study if they are
Between 60 and 80y (inclusive),
Reside in the local (i.e., within 60km of Hamilton) community; and
Are willing and able to provide written informed consent.
Participants must fall into one of three self-reported mobility limitations based on validated screening criteria via a structured phone interview. Potential participants will be asked whether they have any difficulty:
Walking 800m;
Climbing ten steps; and
Transferring from/into a car or bus.
Response options include:
Managing without difficulty;
Managing without difficulty but with task modification; or
Managing with minor difficulty.

You may not qualify if…

Participants who self-report more than minor difficulty will be considered to have a mobility disability and excluded.
Participants who cannot speak or read English will also be excluded.

Where it is running

Exercise Metabolism Research Laboratory, McMaster Univeristy — Hamilton, Ontario, Canada (enrolling)

Full record on ClinicalTrials.gov

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