Inflammatory Challenge and Fear

Recruiting now · Phase 1 · Has a placebo group

Conditions studied: Posttraumatic Stress Disorder (PTSD)

In brief

The goal of this study is to learn if short-term changes in the immune system alter how we process information and experience fear. The main questions it aims to answer are: Do people who receive typhoid vaccine respond differently than those who receive a placebo saline vaccine? Do people who receive typhoid vaccine experience changes in how they think and feel? Participants will: Attend four appointments at the San Francisco VA Health Care System; Receive typhoid vaccine or placebo at one of the visits; Have their physiological responding measured while listening to sounds; Complete questionnaires and psychological tests.

Key facts

Study ID

NCT06630884

Run by

University of California, San Francisco

People needed

288

Starts

2025-03-28

Expected to finish

2028-11-01

Last updated by the study team

2025-12-15

Who can join

Age: 18 and older, up to 60. Sex: any. Healthy volunteers: accepted.

You may qualify if…

• All Subjects:
• Aged 18-60 years old
• Trauma Exposed
• Current PTSD/No history of PTSD

You may not qualify if…

• Contraindications to typhoid vaccine
• Conditions associated with inflammation
• Pregnancy or plans to become pregnant in next three months

Where it is running

• San Francisco VA Health Care System — San Francisco, California, United States (enrolling)

Full record on ClinicalTrials.gov

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