A Master Protocol to Evaluate DCC-3009 in Gastrointestinal Stromal Tumor (GIST)

Recruiting now · Phase 1/Phase 2

Conditions studied: Gastrointestinal Stromal Tumor (GIST)

In brief

The purpose of this Phase 1/2 master protocol study is to evaluate if DCC-3009 is safe, tolerable and works effectively in the treatment of GIST. The study will use a modular approach with each module being defined according to therapy: DCC-3009 alone or DCC-3009 in combination with other anticancer therapies. Each module will be conducted in 2 parts: Part 1 (Dose Escalation) and Part 2 (Dose Expansion). Participants will be treated in 28-day treatment cycles with an estimated duration of up to 2 years.

Key facts

Study ID

NCT06630234

Run by

Deciphera Pharmaceuticals, LLC

People needed

120

Starts

2024-12-10

Expected to finish

2028-05-01

Last updated by the study team

2026-02-05

Who can join

Age: 18 and older. Sex: any. Healthy volunteers: not accepted.

You may qualify if…

• Module A Part 1 (Escalation):
• Any participant with histologically or cytologically confirmed advanced/unresectable or metastatic GIST with documented KIT or platelet-derived growth factor receptor alpha (PDGFRA) mutation, who has progressed on or was intolerant to at least 1 approved tyrosine kinase inhibitor (TKI) regimen in the advanced/metastatic setting
• Have at least 1 measurable lesion as defined by mRECIST, v1.1
• Have Eastern Cooperative Oncology Group (ECOG) Performance Status (PS) of 0 or 1
• Adequate organ function, bone marrow function, and electrolytes
• All participants agree to comply with the contraception requirements
• Have a life expectancy of more than 3 months

You may not qualify if…

• Received systemic anticancer therapy or radiotherapy within 14 days prior to first dose of study drug
• Prior or concurrent malignancy that requires treatment or is expected to require treatment for active cancer
• Has known active central nervous system (CNS) metastases or an active primary CNS cancer
• History or presence of clinically relevant cardiovascular abnormalities
• Major surgery within 28 days of the first dose of study drug
• Had systemic arterial thrombotic or embolic events within 6 months prior to the first dose of study drug
• Had venous thrombotic events (e.g., deep vein thrombosis) or venous thrombotic embolic events (e.g., pulmonary embolism) within 1 month prior to the first dose of study drug
• Known allergy or hypersensitivity to any component of the study drug
• Malabsorption syndrome or other illness that could affect oral absorption
• Any other clinically significant comorbidities

Where it is running

• HonorHealth — Scottsdate, Arizona, United States (enrolling)
• UC San Diego Moores Cancer Center — La Jolla, California, United States (enrolling)
• University of Colorado Anschutz Medical Campus — Aurora, Colorado, United States (enrolling)
• Mayo Clinic Florida — Jacksonville, Florida, United States (enrolling)
• University of Miami - Sylvester Comprehensive Cancer Center — Miami, Florida, United States (enrolling)
• Dana Farber Cancer Institute — Boston, Massachusetts, United States (enrolling)
• START Midwest — Grand Rapids, Michigan, United States (enrolling)
• Mayo Clinic Rochester — Rochester, Minnesota, United States (enrolling)
• Memorial Sloan Kettering Cancer Center — New York, New York, United States (enrolling)
• Vanderbilt University-Ingram Cancer Center — Nashville, Tennessee, United States (enrolling)

Full record on ClinicalTrials.gov

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