Brain Blood Vessel Responses to Changes in Blood Flow: Younger Cohort

Recruiting now · Phase 2 · Has a placebo group

Conditions studied: Magnetic Resonance Imaging, Cerebrovascular Circulation

In brief

Brain blood flow will be measured during a simulated postural change test and while breathing increased levels of carbon dioxide using magnetic resonance imaging.

Key facts

Study ID

NCT06629090

Run by

University of Wisconsin, Madison

People needed

36

Starts

2025-12-17

Expected to finish

2027-05-01

Last updated by the study team

2026-07-06

Who can join

Age: 20 and older, up to 40. Sex: any. Healthy volunteers: accepted.

You may qualify if…

• Between the ages of 20-40 years
• Have a BMI ≤34.5 kg/m2
• are less than 72 in (182.88 cm) height
• Nonsmoker

You may not qualify if…

• Diagnosis of Mild Cognitive Impairment (MCI) or Alzheimer's disease (AD)
• History or evidence of hepatic disease, hematological disease, or peripheral vascular disease; severe kidney injury requiring hemodialysis
• History of cardiovascular disease including: severe congestive heart failure, coronary artery disease, ischemic heart disease (stents, coronary artery bypass grafts) and tachycardia
• Uncontrolled hypertension
• History of clinically significant ischemic or hemorrhagic stroke, or significant cerebrovascular disease
• Severe untreated obstructive sleep apnea
• History of diabetes with HbA1c greater than 9.5 percent
• Major neurologic disorders other than dementia (e.g., MS, ALS, brain surgery, etc.)
• Current or recent (less than1 year) major psychiatric condition (Axis I) or addictive disorders
• Significant surgical history
• Other significant medical conditions at investigators' discretion
• Contraindications to MRI
• Prescribed medications that interfere with prazosin
• Lactose allergy
• lower body will not fit in lower body negative pressure (LBNP) chamber (regardless of overall height and BMI)

Where it is running

• University of Wisconsin — Madison, Wisconsin, United States (enrolling)

Full record on ClinicalTrials.gov

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