Improving Detection of Early Lung Cancer in a Diverse Population (IDEAL) Study

Recruiting now · Not applicable

Conditions studied: Lung Cancer, Pulmonary Nodule

In brief

The goal of this trial is to (a) identify people at high risk of lung cancer who would benefit from LDCT screening but are currently ineligible based on current lung cancer screening criteria (b) provide the framework to manage patients with Incidental Pulmonary Nodules (IPNs) with appropriate follow-up based on accurate interpretation of the Chest CT scan that is already available and (c) develop a simple, point-of-care, minimally invasive test, focusing on the breath and circulating blood proteins, to detect lung cancer, and develop a method to differentiate between cancerous and non-cancerous nodules using a single. Participants will be asked to answer a questionnaire regarding their age, race/ethnicity, smoking history, and residential history if they have ever been told they have chronic obstructive pulmonary disease (COPD), high blood pressure, education level, medications and height and weight. Participants will then be asked to give a breath sample via the breath collection device. All this information will be collected before the breath collection. After that, participants will give 1-2 tablespoons of blood. CT scans with IPN(s) will be reviewed and run through a computer detection software to identify nodules, followed up as per current clinical guidelines.

Key facts

Study ID

NCT06628102

Run by

British Columbia Cancer Agency

People needed

3600

Starts

2023-08-04

Expected to finish

2028-12-31

Last updated by the study team

2024-10-04

Who can join

Age: 50 and older, up to 80. Sex: any. Healthy volunteers: accepted.

You may qualify if…

• Age 50-80
• Able to consent
• Chest CT positive for nodule equal to or greater than 6mm
• No additional other cancer- (outside of lung cancer for group 1)
• Must be able to abstain from smoking tobacco for 24 hours prior to the breath test.

You may not qualify if…

• Too sick to provide a breath sample
• you have smoked in the last 24 hours
• You are pregnant
• You have been diagnosed with a respiratory infection in the last 3 months
• Unwilling to consent to the study

Where it is running

• BC Cancer Research, part of the Provincial Health Authority — Vancouver, British Columbia, Canada (enrolling)

Full record on ClinicalTrials.gov

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