Radical Surgery for Advanced Gastric- or GEJ-cancer With Oligometastatic Dissmination to the Liver

Recruiting now · Not applicable

Conditions studied: Survival

In brief

Offering treatment with potential to cure for participants with no such offer in today's standard treatment options, by offering metastatectomia and standard treatment with intention to cure i.e., neoadjuvant chemotherapy and gastrectomy for participants with gastric- og gastroeusofageal junction cancer. Including 20 participants from all 4 centres in Denmark able to perform the surgical procedures in question. Endpoints: 2-year overall survival.

Key facts

Study ID

NCT06627634

Run by

Aarhus University Hospital

People needed

20

Starts

2020-12-01

Expected to finish

2024-12-01

Last updated by the study team

2024-10-04

Who can join

Age: 18 and older. Sex: any. Healthy volunteers: not accepted.

You may qualify if…

• Age > 18.
• Presence of primary T1-T4N0-N3M1 adenocarcinoma of the stomach or GEJ and max. 30% liver involvement.
• Primary tumour resectable, based on imaging workup.
• Surgical operable patients with ASA-score36 ≤ III and WHO performance status37 0-1.
• Patients eligible for treatment with systemic chemotherapy by FLOT regimen.
• Informed consent is obtained.

You may not qualify if…

• Patient with non-resectable cancer.
• Direct growth involving adjacent organs, i.e., pancreas, colon, blood vessels or bones.
• Other malignant disease diagnosed or treated up to 2 years prior to inclusion, except non-aggressive cancers such as non-melanoma sin cancer.
• Altered anatomy of the upper gastrointestinal tract due to previous surgery of the oesophagus, stomach, and duodenum.
• BMI ≤ 18
• The patient is unable to understand and/or read the consent form.
• Other serious illness or acute infections.
• Pregnant or breastfeeding.

Where it is running

• Aarhus Univercity hospital — Aarhus, Jylland, Denmark (enrolling)

Full record on ClinicalTrials.gov

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