Liberal or Adhere to Recommendations for PCC Management in Major Bleeding Following Trauma

Recruiting now · Not applicable

Conditions studied: Traumatic Bleeding

In brief

Severe post-traumatic bleeding remains a major challenge in trauma management . The effectiveness and safety of PCC in the treatment of major traumatic bleeding is controversial, and the indications for use are not clear. Studies on the status of PCC use and the efficacy evaluation of PCC adhere to recommendations are lacking.

Key facts

Study ID

NCT06627218

Run by

Second Affiliated Hospital, Zhejiang University, School of Medicine

People needed

650

Starts

2021-01-01

Expected to finish

2025-12-31

Last updated by the study team

2024-10-04

Who can join

Age: 18 and older, up to 80. Sex: any. Healthy volunteers: not accepted.

You may qualify if…

• Age ≥18 years old or < 80 years old
• Trauma treated in resuscitation unit/emergency room patient
• Hospital admission within 24h after injury
• Assessment of blood consumption (ABC) score ≥2 points.

You may not qualify if…

• PCC was used before admission
• Anticoagulant drugs (such as low molecular weight heparin, rivaroxaban, warfarin, etc.)
• Previous venous thrombosis (VTE, Patients with a history of coronary artery stents within 3 months of pulmonary embolism and myocardial infarction)
• Patients with traumatic cardiac arrest in hospital
• Women during breastfeeding, pregnancy or pregnancy
• Patients with hemophilia A and other blood system diseases, severe liver disease, cirrhosis and other coagulation dysfunction

Where it is running

• Department of Emergency medicine, Second Affiliated Hospital, School of Medicine& Institute of Emergency medicine, Zhejiang University, — Hangzhou, Zhejiang, China (enrolling)

Full record on ClinicalTrials.gov

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