Treating Chronic Pain of Peripheral Nerve Origin With the Novel Noninvasive Hypersound Neuromodulation System

Starting soon · Early Phase 1

Conditions studied: Chronic Knee Pain, Chronic Knee Osteoarthritis, Post Surgical Neuropathic Pain

In brief

First, the subject will undergo screening and provide informed consent. Baseline measurements are then taken. The subject remains seated with back support throughout the session. The technician verifies and marks the knee for treatment and wraps an antenna applicator strap around the lower leg near the knee. The device is turned on in test mode to confirm the therapy location, with the subject identifying when they feel a sensation over their pain area. The power threshold for this sensation is recorded. The therapy, which lasts 15 minutes, is delivered at 90% of this threshold to ensure the subject does not feel it. After therapy, post-treatment measurements are taken.

Key facts

Study ID

NCT06626854

Run by

Hypersound Medical Inc

People needed

5

Starts

2026-06-10

Expected to finish

2026-12-10

Last updated by the study team

2026-02-23

Who can join

Age: 18 and older, up to 75. Sex: any. Healthy volunteers: not accepted.

You may qualify if…

• Pain greater than mid-range using standardized pain inventory (SPI).
• No medication for pain both over-the-counter and by prescription for 24 hours prior to treatment.
• Body mass index (BMI) to be calculated for all participants with limitation for any BMI that is lower than normal. (Target is normal, overweight or obese).
• Age greater than 18.

You may not qualify if…

• Existing Peripheral Nerve Stimulator Implant in the lower extremities

Full record on ClinicalTrials.gov

Trial information comes from ClinicalTrials.gov and is refreshed daily. TrialsForMe does not provide medical care and does not run the studies it lists.