A Study of the Effect of Nemtabrutinib (MK-1026) on the Plasma Levels of Digoxin in Healthy Participants (MK-1026-012)

Completed · Phase 1

Conditions studied: Healthy

In brief

The goal of the study is to learn what happens to levels of digoxin in a healthy person's body over time. Researchers will compare what happens to digoxin in the body when it is given with and without another medicine called nemtabrutinib. Researchers are testing if digoxin levels in the body are different when digoxin is given with or without nemtabrutinib.

Key facts

Study ID

NCT06625827

Run by

Merck Sharp & Dohme LLC

People needed

24

Starts

2023-11-07

Expected to finish

2024-01-22

Last updated by the study team

2024-10-03

Who can join

Age: 18 and older, up to 55. Sex: any. Healthy volunteers: accepted.

You may qualify if…

• Is in good health based on medical history, physical examination, vital signs (VS) measurements, electrocardiograms (ECGs), and laboratory safety tests performed before randomization
• Has a body mass index (BMI) 18.0 to 32.0 kg/m\^2 (inclusive)

You may not qualify if…

• Has a medical history that may confound the results of the study or poses an additional risk to the participant in the study
• Has a hypersensitivity to digoxin and/or to other digitalis preparations including inactive ingredients (eg, lactose, corn starch and potato starch)

Where it is running

• ICON (Site 0001) — Lenexa, Kansas, United States

Full record on ClinicalTrials.gov

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