A Study of Levothyroxine and Enlicitide Decanoate (MK-0616) in Healthy Adult Participants (MK-0616-028)

Completed · Phase 1

Conditions studied: Healthy

In brief

Levothyroxine (T4) is a man-made thyroid hormone used to treat certain thyroid conditions. After taking levothyroxine, a person's body changes it to triiodothyronine (T3). The amount of levothyroxine in a person's blood must be carefully controlled to maintain proper function. Enlicitide decanoate was designed to lower the amount of cholesterol in a person's blood. Researchers want to learn about levothyroxine when taken at the same time with enlicitide decanoate. They want to: * Measure a person's blood to find out if the amount of levothyroxine in the blood is the same when levothyroxine is taken alone or with enlicitide decanoate * Learn about the safety of levothyroxine when taken alone or with enlicitide decanoate and if people tolerate it

Key facts

Study ID

NCT06625814

Run by

Merck Sharp & Dohme LLC

People needed

28

Starts

2024-07-08

Expected to finish

2024-09-11

Last updated by the study team

2024-10-03

Who can join

Age: 19 and older, up to 50. Sex: any. Healthy volunteers: accepted.

You may qualify if…

• The key inclusion criteria include but are not limited to the following:
• Medically healthy with no clinically significant medical history
• Continuous non-smoker who has not used nicotine- and tobacco-containing products for at least 3 months prior to the first dosing

You may not qualify if…

• The key exclusion criteria include but are not limited to the following:
• History of cardiovascular disease or diabetes mellitus
• History of cancer

Where it is running

• Celerion (Site 0001) — Lincoln, Nebraska, United States

Full record on ClinicalTrials.gov

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