Quantification of Phosphorylated Alpha-synuclein in Cutaneous Biopsies as a Prospective Biomarker in Parkinson's Disease

Running, not enrolling

Conditions studied: REM Behavior Disorder, Parkinson Disease

In brief

This study aims to assess the levels of phosphorylated alpha-synuclein (P-SYN) in patients with Parkinson's disease and REM Behavior Disorder using a minimally invasive skin punch biopsy. It seeks to understand the natural progression of P-SYN deposition over time to explore the potential of P-SYN quantification as a biomarker for disease progression.

Key facts

Study ID

NCT06621602

Run by

CND Life Sciences

People needed

100

Starts

2024-12-17

Expected to finish

2027-04-01

Last updated by the study team

2026-02-11

Who can join

Age: 50 and older, up to 85. Sex: any. Healthy volunteers: not accepted.

You may qualify if…

• Male and female 50 to 85 years of age
• Clinical confirmed diagnosis of Parkinson's disease or REM Sleep Behavior

You may not qualify if…

• Clinical evidence of severe vascular disease (history of ulceration, poor wound healing or vascular claudication)
• History of allergic reaction to Lidocaine for local anesthesia needed for skin biopsies
• Use of blood thinners (Plavix or Aspirin used separately is allowed)
• Significantly impaired wound healing or history of scarring or keloid formation

Where it is running

• CND Life Sciences — Scottsdale, Arizona, United States
• Movement Disorders Center of Arizona — Scottsdale, Arizona, United States
• Parkinson's Research Centers of America - Orange County — Aliso Viejo, California, United States
• Cedars Sinai — Los Angeles, California, United States
• Parkinson's Research Centers of America - Palo Alto — Palo Alto, California, United States
• University of Colorado — Aurora, Colorado, United States
• Aventura Neurologic Associates, LLC — Aventura, Florida, United States
• Parkinson's Disease and Movement Disorders Center - Boca Raton — Boca Raton, Florida, United States
• Atlanta NeuroScience Institute ANI — Atlanta, Georgia, United States
• Parkinson's Disease and Movement Disorders Center at KUMC — Kansas City, Kansas, United States
• Neurology Multidisciplinary Clinic at Norton Healthcare — Louisville, Kentucky, United States
• MedStar Montgomery Medical Center — Olney, Maryland, United States
• Boston Neuro Research Center — Boston, Massachusetts, United States
• Parkinson's Research Centers of America - Long Island — Commack, New York, United States
• University of Rochester — Rochester, New York, United States
• The Medical University of South Carolina — Charleston, South Carolina, United States
• Veracity Neuroscience LLC — Memphis, Tennessee, United States
• UT Health San Antonio — San Antonio, Texas, United States

Full record on ClinicalTrials.gov

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