AMD and Validation Rod-Meditated Dark Adaptation With Everyday Task Performance
Recruiting now · Not applicable
Conditions studied: Age-Related Macular Degeneration
In brief
The goal is to conduct a cross-sectional, single timepoint study on older adults with early and intermediate AMD, and with subretinal drusenoid deposits (SDD), and those in normal health, establishing an association between dark adaptation and reading performance under dim illumination, both which depend on rod photoreceptors.
Key facts
- Study ID
- NCT06619405
- Run by
- Duke University
- People needed
- 100
- Starts
- 2025-08-15
- Expected to finish
- 2027-12-31
- Last updated by the study team
- 2025-08-21
Who can join
Age: 50 and older, up to 89. Sex: any. Healthy volunteers: accepted.
You may qualify if…
- Capable and willing to provide consent
- Has been diagnosed with early, intermediate dry age-related macular degeneration or geographic atrophy or has a healthy macular for controls
- At least 50 years of age
You may not qualify if…
- Unable or unwilling to give consent or unable to read consent since the study involves testing which requires reading
- Under 50 years of age
- Presence of dense cataracts in the study eye (s) that can affect visual function tests
- Presence of glaucoma requiring treatment during the study and/or visual field defects
- Previous retinal laser or surgical therapy in the study eye(s)
- Previous retinal laser or surgical therapy in the study eye(s)
- Any other ocular condition requiring long-term therapy or surgery during the study
- The participant has photographically significant corneal or media opacities in either eye that would preclude adequate ophthalmic imaging and functional testing
- Diagnosis of nystagmus that will interfere with testing
- High myopia -8 Diopters or more severe
- The participant has, in the opinion of the Investigator, any physical or mental condition that would increase the risk of participation in the study or may interfere with the study procedures, evaluations, and outcome assessments.
Where it is running
- Duke Eye Center — Durham, North Carolina, United States (enrolling)
Full record on ClinicalTrials.gov
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