Connectomic Guided DBS for Parkinson's Disease

Enrolling by invitation · Not applicable

Conditions studied: Parkinson Disease, Tremor, Dyskinesias

In brief

The objective of this research is to use advanced connectomic imaging models to identify disease-relevant axonal pathway targets for better tremor control in Parkinson's disease patients while avoiding undesirable side effects, with the goal of increasing precision and facilitating the choice of optimal DBS parameters for certain disease phenotypes. The investigators hypothesize that patient centered subthalamic nucleus deep brain stimulation of cerebellothalamic axonal pathways and pallidothalamic tract activation can provide better tremor control while avoiding worsening dyskinesias in patients with Parkinson's disease with significant tremor.

Key facts

Study ID

NCT06618157

Run by

Duke University

People needed

20

Starts

2026-02-16

Expected to finish

2027-01-29

Last updated by the study team

2026-02-20

Who can join

Age: 18 and older. Sex: any. Healthy volunteers: not accepted.

You may qualify if…

• Age 18 or older
• Diagnosed with Parkinson's disease and has previously been implanted with bilateral subthalamic nucleus deep brain stimulation (DBS)
• Received DBS at least three months prior to the time of the study to allow for optimization of usual clinical care
• With at least mild tremor on a pre-operatory MDS-UPDRS clinical scale as defined by at least 2 out of 4 resting tremor grading on MDS-UPDRS on at least one extremity

You may not qualify if…

• Not having a post-operative head CT with 1mm or smaller axial slices at least 1 week after initial lead implantation.
• Patients who received DBS less than three months prior to the start of the study

Where it is running

• Duke Health Center at Morreene Road — Durham, North Carolina, United States

Full record on ClinicalTrials.gov

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