Closed Loop Spinal Cord Stimulation for Chemotherapy Induced Peripheral Neuropathy, a Pilot Study.

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Conditions studied: Peripheral Neuropathy Due to Chemotherapy

In brief

To explore the benefits of using closed loop spinal cord stimulation (SCS) in the treatment of patients experiencing painful chemotherapy induced peripheral neuropathy (CIPN) by assessing changes in pain, quality of life, pain medication use, sensory improvement through quantitative sensory testing, and improvement of gait through quantitative gait testing.

Key facts

Study ID

NCT06616649

Run by

M.D. Anderson Cancer Center

People needed

10

Starts

2025-07-14

Expected to finish

2027-07-01

Last updated by the study team

2026-05-20

Who can join

Age: 18 and older. Sex: any. Healthy volunteers: not accepted.

You may qualify if…

• Age ≥18 years
• Diagnosis history of CIPN of lower extremities
• Patients with a prior or concurrent malignancy whose natural history or treatment does not have the potential to interfere with the safety or efficacy assessment of SCS
• Ability to understand and the willingness to sign a written informed consent document.

You may not qualify if…

• Patients undergoing active chemotherapy or immunotherapy
• Patients undergoing medical litigation.
• Patients with active infection, being treated with antibiotics
• Patients that are pregnant or planning to conceive
• Patients who are receiving any investigational agents.
• Patients with brain metastases.
• Patients with cognitive impairment/psychiatric illness/social situations that would limit compliance with study requirements.
• Patients with history of alternative forms of sensorimotor neuropathies prior to CIPN presentation

Where it is running

• The University of Texas MD Anderson Cancer Center — Houston, Texas, United States

Full record on ClinicalTrials.gov

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