How Does the Type of Waveform Affect Tolerability With Transcutaneous Auricular Vagus Nerve Stimulation?

Completed · Not applicable

Conditions studied: Healthy

In brief

The purpose of this research study is to investigate the effects of different forms of a gentle form of electrical stimulation applied to the ear, known as transcutaneous auricular vagus nerve stimulation (taVNS). The research team is interested in how the different forms affect comfort and tolerability, as well as how well it works.

Key facts

Study ID: NCT06614933
Run by: University of Miami
People needed: 30
Starts: 2024-12-15
Expected to finish: 2025-06-07
Last updated by the study team: 2026-05-28

Who can join

Age: 18 and older, up to 80. Sex: any. Healthy volunteers: accepted.

You may qualify if…

between the ages of 18-80 years
English speaking (must be able to consent and complete the interviews in English)

You may not qualify if…

chronic pain (average intensity \>2/10 on 0-10 scale, for longer than 3 months)
acute pain of intensity greater than 3/10
chronic inflammatory conditions that are poorly controlled (e.g., diabetes, autoimmune disease)
any unstable medical condition or medical contraindication to moderate physical exertion (e.g., unstable angina or cardiac arrythmia)
pregnancy
currently taking Buprenorphine or recently stopped taking (within 1 month)
presence of cognitive impairment or language barrier that impairs full autonomy in the consent process or in the ability to participate in detailed interviews
implants in the head or neck, cochlear implants, or pacemaker
head or neck metastasis or recent ear trauma
history of epilepsy
history of autonomic nervous system dysfunction (e.g., postural orthostatic tachycardia syndrome).

Where it is running

University of Miami, Plumer Building — Coral Gables, Florida, United States

Full record on ClinicalTrials.gov

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