AdLip: Human Coach-supported Digital/AI Personal Health Assistant to Improve Adherence to Lipid-Lowering Medication

Recruiting now · Not applicable

Conditions studied: Hyperlipidemia, Medication Nonadherence

In brief

Investigators hypothesize that the use of a human coach-supported digital/AI personal health assistant (app) will improve adherence to cholesterol-lowering medications (statins with or without ezetimibe) among patients with hyperlipidaemia and suboptimal LDL-C control, when compared to standard care.

Key facts

Study ID

NCT06614049

Run by

National University of Singapore

People needed

450

Starts

2024-06-10

Expected to finish

2026-02-14

Last updated by the study team

2024-10-03

Who can join

Age: 21 and older, up to 84. Sex: any. Healthy volunteers: accepted.

You may qualify if…

• Between 21 to 84 years old
• Prescribed statins with or without ezetimibe for hyperlipidaemia.
• Medication non-adherence as defined by the \"Extent to Non-adherence\" sub-scale of the DOSE Non-Adherence Measure), with a score \> 1 (range from 0-15)
• Singapore residents (citizens, permanent residents, or long-term pass holders).
• In possession of a smartphone or tablet with Android or iOS operating systems.
• Have internet access on their mobile devices.

You may not qualify if…

• Does not read or understand English. Current use of smartphone medication adherence app(s) that include statins.
• Concurrent use of PCSK9 Inhibitors in addition to statins and/or ezetimibe
• Participation in another study that uses medications that could affect lipid levels
• Severe renal impairment defined as chronic kidney disease stage 4 and above.
• Severe liver disease (Child-Pugh Class C)
• Existing muscular-related complaints or diagnoses which may confound adverse event reporting
• Uncorrected thyroid conditions, especially poorly-controlled hypothyroidism
• Documented psychiatric diagnosis or history of mental illness or deemed as unable to give informed consent.
• Currently pregnant, breastfeeding or expecting to get pregnant during the course of the study (1 year).
• Guarded prognosis with expectant mortality within 12 months or less.

Where it is running

• National Healthcare Group Polyclinics — Singapore, Singapore (enrolling)
• National University Polyclinics — Singapore, Singapore (enrolling)

Full record on ClinicalTrials.gov

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