Intravenous Acetaminophen After Cardiac Surgery - Definitive Study
Recruiting now · Phase 4 · Has a placebo group
Conditions studied: Post Operative Delirium, Post Operative Pain, Post-Op Complication, Post-cardiac Surgery
In brief
Double blind, double dummy trial of the use of IV acetaminophen versus oral acetaminophen for the prevention of delirium after cardiac surgery. The underlying hypothesis is that better pain control and less use of narcotics will lead to a lower incidence of delirium from day 1 to 7 following cardiac surgery. Other important secondary outcomes are the total use of narcotics, ICU and hospital stay, improved cognitive function at 6 months and 1 year post surgery, NSAID use at each centre and associated NSAID complications.
Key facts
- Study ID
- NCT06613178
- Run by
- McGill University Health Centre/Research Institute of the McGill University Health Centre
- People needed
- 1100
- Starts
- 2024-07-02
- Expected to finish
- 2027-12-15
- Last updated by the study team
- 2024-09-25
Who can join
Age: 18 and older. Sex: any. Healthy volunteers: not accepted.
You may qualify if…
- greater or equal to 18
- elective cardiac surgery
- stable pre-operative
- aorto-coronary bypass with or without 1 valve replacement.
You may not qualify if…
- Refusal by surgeon Requested late extubation by surgeon or anesthesia Intra-aortic balloon pump Mechanical cardiac support Sensitivity to acetaminophen Psychiatric history with current active treatment Alzheimer\'s disease Seizure in previous 6 months Recent history of alcohol misuse Cognitive impairment
Where it is running
- University of Manitoba — Winnipeg, Manitoba, Canada (enrolling)
- McGill Universtiy Health Centre — Montreal, Quebec, Canada (enrolling)
- Universite Montreal — Montreal, Quebec, Canada (enrolling)
- University of Laval — Québec, Quebec, Canada (enrolling)
- Sunnybroook Health Centre — Toronto, Ontario, Canada
- Trillium Health Centre — Mississagua, Ontario, Canada
- University of Ottawa — Ottawa, Ontario, Canada
- University of British Columbia — Vancouver, British Columbia, Canada
Full record on ClinicalTrials.gov
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