Acute Vitamin D Supplementation on Testosterone in Females

Running, not enrolling · Not applicable · Has a placebo group

Conditions studied: Female Hormone Profile

In brief

Participation will take place over two visits to the Clinical Exercise Research Center (CERC) at the University of Southern California Health Sciences Campus. On the first visit, height, weight, and body composition by bioelectrical impedance are recorded. Questionnaires and withdrawal of a sample of blood (1 tablespoon) are also completed. The intervention begins the day following the first visit. The intervention protocol consists of three weeks of consuming either a placebo capsule or a 5000 IU Vitamin D capsule daily and completing a daily survey. The second visit to CERC immediately follows the 3-weeks intervention. In this visit, the same blood sampling protocol will be completed. The assignment of the intervention will be randomized (i.e., rolling a die), and participants are blinded to group assignment.

Key facts

Study ID

NCT06610968

Run by

University of Southern California

People needed

20

Starts

2025-07-01

Expected to finish

2026-09-30

Last updated by the study team

2026-03-25

Who can join

Age: 18 and older, up to 35. Sex: female. Healthy volunteers: accepted.

You may qualify if…

• Assigned female at birth
• 18 to 35 years of age
• No chronic diseases affecting the uptake of Vitamin D or causing Vitamin D sensitivity (e.g., sarcoidosis, tuberculosis, Wegener's granulomatosis, other forms of vasculitis, inflammatory bowel diseases, etc.) [21]
• Completion and signature of the informed consent document
• Non-pregnant or trying to become pregnant
• No supplementation with Vitamin D within three months of enrollment
• No documented gynecological disease (e.g., PCOS, endometriosis, etc.)
• Weight greater than or equal to 110 lbs

You may not qualify if…

• Pregnant
• Supplementation with Vitamin D within three months of enrollment
• Taking exogenous hormones
• Documented gynecological disease (e.g., PCOS, endometriosis, etc.)
• Suffering from chronic diseases affecting the uptake of Vitamin D or causing Vitamin D sensitivity (e.g., sarcoidosis, tuberculosis, Wegener's granulomatosis, other forms of vasculitis, inflammatory bowel diseases, etc.) [21]
• Weight less than 110 lbs

Where it is running

• University of Southern California Health Sciences Campus Center for Health Professions — Los Angeles, California, United States

Full record on ClinicalTrials.gov

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