Effects of E-cigarette Use on Health

Recruiting now

Conditions studied: Electronic Cigarette Use

In brief

Electronic nicotine delivery systems (ENDS) are used by millions of Americans, however their long-term health effects are unknown. This research proposal will quantify the effects of long-term ENDS use on validated and novel biomarkers of cardiovascular and pulmonary disease and how they are influenced by use heaviness, age, body weight, and co-use of other products. This study will produce the most informative evidence to date on how long-term ENDS use affects cardiovascular and pulmonary health.

Key facts

Study ID

NCT06610838

Run by

University of Wisconsin, Madison

People needed

600

Starts

2025-01-06

Expected to finish

2029-06-30

Last updated by the study team

2025-12-24

Who can join

Age: 21 and older. Sex: any. Healthy volunteers: accepted.

You may qualify if…

• greater than or equal to 21 years of age
• has vaped a nicotine e-cigarette product at least 2 days/week for most weeks for greater than or equal to 12 months
• plans to remain in catchment area for greater than or equal to 3 years
• smoked 5 or fewer tobacco cigarettes in the past 6 months
• no serious CV, pulmonary, or other medical problems
• not currently pregnant
• no plans to stop vaping

You may not qualify if…

• serious CV, pulmonary, or other medical problems (e.g., moderate or severe aortic stenosis, class III or IV heart failure, blood pressure greater than or equal to 160/100 mmHg, interstitial lung disease, sarcoidosis, Stage 3 or 4 cancer)
• combusted or vaped cannabis use 3 days/week or more in the past 3 months
• currently pregnant
• not able to read an write English
• incarceration

Where it is running

• UW Center for Tobacco Research and Intervention — Madison, Wisconsin, United States (enrolling)

Full record on ClinicalTrials.gov

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