A Study of Bleeding and Treatment in Participants With Von Willebrand Disease

In brief

The purpose of this screening study is to accumulate information regarding bleeding events, quality of life, and the social and clinical impact of bleeds in participants with Von Willebrand Disease (VWD). Data from this study will be used to establish baseline bleeding and treatment rates in a population of participants with VWD and act as comparator data for future clinical study outcomes.(e.g. Velora Pioneer)

Key facts

Study ID: NCT06610201
Run by: Hemab ApS
People needed: 200
Starts: 2024-08-30
Expected to finish: 2026-12-01
Last updated by the study team: 2026-04-21

Who can join

Age: 16 and older. Sex: any. Healthy volunteers: not accepted.

You may qualify if…

Has the ability to provide informed consent to participate in the study, in accordance with applicable regulations.
Has an understanding, ability, and willingness to comply with Study procedures and restrictions.
Is 16 years and < 70 years at the time of screening.
Weight 50 to 120 kg (±10%) at Screening and body mass index (BMI) <38.5 kg/m*2.
Has Von Willebrand Disease: Type 1 VWD (including Type 1C VWD) or Type 2A VWD. All participants must have: Documented lab results confirming their diagnosis consistent with ISTH/ASH diagnostic guidelines; VWF Activity ≤30 IU/dL and FVIII activity ≤70 IU/dL during Screening.
Has symptomatic disease as defined by a history of bruising or bleeding events, with an expected minimum of 3 bleeding episodes (including heavy menstrual bleeding) per year that require treatment to control bleeding symptoms, and/or has recurrent and ongoing episodes of heavy menstrual bleeding at the time of enrollment.

You may not qualify if…

Has a history of clinically significant hypersensitivity associated with monoclonal antibody therapies.
Has a personal history of venous or arterial thrombosis or thromboembolic disease, except for catheter-associated, superficial vein thrombosis events.
Has a high-risk thrombophilia: Homozygous Factor V Leiden (FVL), compound heterozygous FVL/prothrombin gene mutation, antithrombin <50%, congenital protein C and protein S deficiency with levels <50%.
Requires ongoing hemostatic (bleed-prophylaxis) treatment to prevent bleeding
Has other known severe bleeding disorder(s) other than VWD.
Planned major surgery during the study period.
Has other conditions that substantially increase the risk of thrombosis either individually or in combination, at the discretion of the Investigator, including but not limited to: significant family history; BMI >30 and ≤38.5 kg/m² (moderately obese, adjusted for ethnicity and increased central adiposity); reduced mobility; active malignancy; major surgery within 6 weeks preceding Screening; or postpartum within 12 weeks preceding Screening.
Is pregnant or plans to become pregnant within the next 6 months following informed consent sign off.
Has clinically significant cardiovascular disease including, but not limited to: NYHA Class III or IV heart failure, coronary artery disease, uncontrolled arrythmia, moderate to severe valvular heart disease, peripheral vascular disease, and ischemic stroke.
Has other combinations of conditions that substantially increase the risk of cardiovascular events at the discretion of the Investigator including, but not limited to, smoking, uncontrolled hyperlipidemia, and uncontrolled hypertension.
Has any concurrent disease, treatment, medication (including but not limited to ongoing anticoagulation, antiplatelet therapy, or non-steroidal anti-inflammatory drugs or other drugs that affect hemostasis), condition, medication, or abnormality in clinical laboratory tests which may impact on the participant's bleeding symptoms or affect their ability to complete the study, in the Investigator's opinion.
Has received any investigational product within 30 days prior to Screening. If the participant was enrolled and dosed in Velora Pioneer (study HMB-002-102; NCT06754852), they must have completed their End of Study Visit.

Where it is running

Phoenix Children's Hospital — Phoenix, Arizona, United States (enrolling)
Arkansas Children's Hospital — Little Rock, Arkansas, United States (enrolling)
Children's Hospital of Los Angeles — Los Angeles, California, United States (enrolling)
University of Miami Hospital and Clinics, Sylvester Comprehensive Cancer Center — Miami, Florida, United States (enrolling)
Emory Children's Center — Atlanta, Georgia, United States (enrolling)
Innovative Hematology, Inc./Indiana Hemophilia and Thrombosis Center — Indianapolis, Indiana, United States (enrolling)
Tulane University School of Medicine — New Orleans, Louisiana, United States (enrolling)
University of Michigan Hospitals, Department of Hemophilia and Coagulation Disorders — Ann Arbor, Michigan, United States (enrolling)
Mayo Clinic - Rochester — Rochester, Minnesota, United States (enrolling)
Oregon Health & Science University — Portland, Oregon, United States (enrolling)
Hemophilia Center of Western Pennsylvania — Pittsburgh, Pennsylvania, United States (enrolling)
The University of Texas Southwestern Medical Center — Dallas, Texas, United States (enrolling)
Washington Institute For Coagulation (WIC) — Seattle, Washington, United States (enrolling)
Fiona Stanley Hospital — Murdoch, Perth, Australia (enrolling)
Royal Prince Alfred Hospital — Camperdown, Sydney, Australia (enrolling)
The Alfred Hospital — Melbourne, Victoria, Australia (enrolling)
Richmond Pharmacology — London, United Kingdom (enrolling)

Full record on ClinicalTrials.gov

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