Personalized Ultrasound-Guided External Diaphragm Pacing to Improve Outcomes in Invasive Mechanically Ventilated Patients
Recruiting now · Not applicable
Conditions studied: Respiratory Failure, Mechanical Ventilation
In brief
This study aims to explore whether personalized external diaphragm pacing (EDP) guided by real-time diaphragm ultrasound (DU) can improve outcomes for patients on invasive mechanical ventilation. Diaphragm ultrasound will be used to assess each patient's diaphragm function and adjust the pacing intensity, creating a customized treatment plan. By using this individualized approach, the investigators hope to prevent diaphragm muscle weakening, which is a common issue during prolonged ventilation, and improve the chances of successful weaning from the ventilator. The study will also incorporate advanced diaphragm function metrics, such as diaphragm thickening fraction (DTF) and diaphragmatic rapid shallow breathing index (D-RSBI), to enhance the accuracy of treatment and improve patient recovery. This trial aims to improve overall outcomes and quality of care for patients requiring long-term mechanical ventilation.
Key facts
- Study ID
- NCT06609577
- Run by
- Daishan Jiang
- People needed
- 150
- Starts
- 2024-11-01
- Expected to finish
- 2027-08-31
- Last updated by the study team
- 2024-10-22
Who can join
Age: 18 and older, up to 95. Sex: any. Healthy volunteers: not accepted.
You may qualify if…
- Adults ≥18 years of age undergoing invasive mechanical ventilation.
- Expected duration of mechanical ventilation ≥48 hours.
You may not qualify if…
- ICU expected length of stay less than 48 hours
- severe phrenic nerve or diaphragmatic injury that is unable to respond to diaphragmatic pacing.
- Patients who have received or are scheduled to receive other respiratory assistance or diaphragmatic pacing interventions.
- Patients with end-stage disease with an expected survival of \<6 months.
- Patients who are unable to be weaned from mechanical ventilation, such as patients with severe brain injury or paraplegia.
Where it is running
- Affiliated Hospital of Nantong University — Nantong, Jiangsu, China (enrolling)
Full record on ClinicalTrials.gov
Trial information comes from ClinicalTrials.gov and is refreshed daily. TrialsForMe does not provide medical care and does not run the studies it lists.