Neural Mechanisms Connecting Deficient Sleep and Smoking Relapse

Recruiting now · Phase 2

Conditions studied: Tobacco Use, Tobacco Cessation, Insomnia

In brief

The study aims to investigate whether behavioral interventions promote cessation in adult smokers by ameliorating negative emotions and improving self-control and identify the neural markers of these effects.

Key facts

Study ID

NCT06609369

Run by

Yale University

People needed

114

Starts

2025-04-21

Expected to finish

2029-06-01

Last updated by the study team

2026-06-05

Who can join

Age: 18 and older, up to 65. Sex: any. Healthy volunteers: not accepted.

You may qualify if…

• English literate
• report heavy tobacco use (including nicotine e-cigarettes) for >6 months
• meet biochemical cut off for recent cigarette smoking or e-cigarette use
• optimal body mass index

You may not qualify if…

• currently enrolled in other treatments
• neuropsychiatric exclusions that could interfere with study participation, increase risk of adverse events, and/or induce deficient sleep
• medical contraindications for fMRI, varenicline, and/or behavioral treatment
• factors that cause deficient sleep and for which behavioral treatment has less benefit
• women who are pregnant or nursing

Where it is running

• Connecticut Mental Health Center — New Haven, Connecticut, United States (enrolling)
• Yale University — New Haven, Connecticut, United States (enrolling)

Full record on ClinicalTrials.gov

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