A Study of REGN7544 for the Treatment in Adult Patients With Sepsis-Induced Hypotension
Completed · Phase 2 · Has a placebo group
Conditions studied: Sepsis-Induced Hypotension
In brief
This study is researching an experimental drug called REGN7544 (called "study drug"). The study is focused on adult patients (18 to 85 years) hospitalized due to a serious infection (called "sepsis") and receiving standard-of-care medications for low blood pressure (called "vasopressors") due to sepsis. The aim of the study is to see how safe, tolerable, and effective the study drug is by observing the effects on blood pressure and the total amount of vasopressor dose received during the stay in the hospital. The study is looking at several other research questions, including: * How the study drug changes the blood pressure and the amount of intravenous (IV) fluids given to participants with low blood pressure due to sepsis * What side effects may happen from taking the study drug * How much study drug is in the blood at different times * Whether the body makes antibodies against the study drug (which could make the drug less effective or could lead to side effects)
Key facts
- Study ID
- NCT06608901
- Run by
- Regeneron Pharmaceuticals
- People needed
- 76
- Starts
- 2025-05-05
- Expected to finish
- 2026-04-28
- Last updated by the study team
- 2026-05-20
Who can join
Age: 18 and older, up to 85. Sex: any. Healthy volunteers: not accepted.
Where it is running
- University of Arizona — Tucson, Arizona, United States
- Yale University — New Haven, Connecticut, United States
- Emory University Hospital — Atlanta, Georgia, United States
- Johns Hopkins Hospital — Baltimore, Maryland, United States
- Massachusetts General Hospital — Boston, Massachusetts, United States
- Harvard Medical School - Beth Israel Deaconess Medical Center — Boston, Massachusetts, United States
- New York University Langone Health Brooklyn Hospital — Brooklyn, New York, United States
- Bellevue Hospital — New York, New York, United States
- New York University Langone Health Tisch-Kimmel Hospital — New York, New York, United States
- Montefiore Medical Center - Weiler Hospital — The Bronx, New York, United States
- Montefiore Medical Center - Moses Campus — The Bronx, New York, United States
- Atrium Health — Winston-Salem, North Carolina, United States
- Cleveland Clinic Foundation — Cleveland, Ohio, United States
- MUSC SCTR Research Nexus Clinic and Lab — Charleston, South Carolina, United States
- Vanderbilt University Medical Center — Nashville, Tennessee, United States
- Intermountain Medical Center - Murray (Pulmonary Medicine) — Murray, Utah, United States
- Centre Hospitalier Regional Universaitaire de Tours (CHRU de Tours) — Tours, Centre-Val de Loire, France
- CHU Dupuytren — Limoges, New Aquitaine, France
- Centre Hospitalier Le Mans — Le Mans, Pays de la Loire Region, France
- Centre Hospitalier Departemental (CHD) Vendee — La Roche-sur-Yon, Vendee, France
- Centre Hospitalier Universitaire Angers — Angers, France
- Raymond Poincare University Hospital — Garches, France
- Paris-Saclay University Hospitals — Le Kremlin-Bicêtre, France
- CHU Nantes — Nantes, France
- Centre Hospitalier Universitaire d'Orleans — Orléans, France
Full record on ClinicalTrials.gov
Trial information comes from ClinicalTrials.gov and is refreshed daily. TrialsForMe does not provide medical care and does not run the studies it lists.