MOLyF : Bone Marrow and Follicular Lymphoma

Recruiting now · Not applicable

Conditions studied: Lymphoma, Follicular

In brief

This is a prospective single-center study designed to assess potential differences in cell composition between bone marrows of patients with follicular lymphoma and those from control subjects. Follicular lymphoma is the most common indolent lymphoma. It is characterised by systematic relapses and bone marrow dissemination in 70% of patients at the time of diagnosis. Although relapses are thought to be related to refractory tumour cells nested in a supportive microenvironment in the bone marrow, the mechanisms involved are poorly understood. To study the specificities of the bone marrow of patients with follicular lymphoma, It is necessary to compare them with control samples. This study takes advantage of surgeries involving sternotomies to recover lost bone marrow and establish a bone marrow bank of patients without hematological disease. This bank will be used to set up control cohorts for other clinical trials involving patients with follicular lymphoma.

Key facts

Study ID

NCT06608147

Run by

Rennes University Hospital

People needed

200

Starts

2024-12-04

Expected to finish

2034-10-01

Last updated by the study team

2024-12-10

Who can join

Age: 18 and older. Sex: any. Healthy volunteers: accepted.

You may qualify if…

• Major patient
• Patient hospitalized in the thoracic, cardiac and vascular surgery department for surgery involving a sternotomy
• Patient with free, informed, written consent
• Patient covered by a health insurance scheme

You may not qualify if…

• History of haematological malignancy or haemogram disturbance
• Immunomodulating treatment: immunosuppressants, corticoids, antineoplastics
• Persons covered by articles L. 1121-5 to L. 1121-8 and L. 1122-1-2 of the French Public Health Code (e.g. minors, protected adults, etc.)].

Where it is running

• CHU Rennes — Rennes, France (enrolling)

Full record on ClinicalTrials.gov

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