Determining Which Regions of the Brain Are Active During Flight Simulation at Separate Timepoints During Training

Completed · Not applicable

Conditions studied: Cognitive Performance

In brief

The overall objective is to identify the cognitive circuits associated with military aviator performance by analyzing what anatomic regions of the brain are functionally "active" (neuronal circuit) while being performing virtual flight simulations, the Precision Instrument Control Task (PICT). The flight simulation test will be conducted at two separate timepoints while the subject is receiving a Functional Magnetic Resonance Imaging (fMRI) scan to evaluate which anatomic and functional brain function is associated with precise performance. By scanning at multiple time points we aim to quantify changes in functional and anatomic connectivity that occur throughout the course of training.

Key facts

Study ID

NCT06606925

Run by

The Geneva Foundation

People needed

35

Starts

2023-09-19

Expected to finish

2026-07-10

Last updated by the study team

2026-07-15

Who can join

Age: 18 and older, up to 54. Sex: any. Healthy volunteers: not accepted.

You may qualify if…

• Active Duty Military Pilots (Instructor Pilot Trainees or Remote Piloted Aircraft Trainees)
• Age 18-54 years
• Biological male or female

You may not qualify if…

• Age < 18 years
• Age > 60 years
• Non-active-duty members
• History of recurrent migraine headaches requiring chronic suppressive medication or prescription drug intervention more frequently than once per year.
• History of head trauma or traumatic brain injury with any loss of consciousness or with confusion or amnesia of greater than five minutes.
• History of eye trauma related to a metallic object unless the presence of residual metal has been previously excluded by x-ray.
• Pregnancy
• History of significant neurological disease including cerebrovascular disease, demyelinating disease, or infections of the central nervous system (encephalitis, meningitis).
• History of medical conditions with potential neurological involvement such as obstructive sleep apnea, autoimmune disorders, etc.
• History of seizures since age six.
• Claustrophobia or intolerance of the MRI without medication.
• Any medical contraindication to MRI (ex: foreign bodies, non-MRI compatible pacemaker, metal devices).

Where it is running

• Joint Base San Antonio - Randolph &amp; Lackland — San Antonio, Texas, United States

Full record on ClinicalTrials.gov

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