Understanding the Transition from Normal Melanocytes to Nevus to Melanoma

Recruiting now

Conditions studied: Congenital Melanocytic Nevi, Melanoma, Skin, Nevi and Melanomas

In brief

The primary objective of this study is to identify the molecular identity profiles of all cellular states that characterize the progression from benign nevi to malignant melanoma in CAYA patients with L/GCMN. The secondary objectives are: * To longitudinally characterize the cell-free DNA (cfDNA) from CAYA patients. * To improve the early diagnosis and treatments for intermediate conditions such as L/GCMN through evidence-based interpretation of personal risk from endogenous or exogenous sources. * To test pre-clinical strategies to best model and improve patient response.

Key facts

Study ID

NCT06605417

Run by

Fundacion Clinic per a la Recerca Biomédica

People needed

100

Starts

2024-01-01

Expected to finish

2026-11-30

Last updated by the study team

2025-02-27

Who can join

Age: any. Sex: any. Healthy volunteers: not accepted.

You may qualify if…

• Congenital nevus with estimated size of 20 cm
• Be over 18 years of age

You may not qualify if…

• No available biological material
• Not having signed the informed consent

Where it is running

• French National Institute of Health and Medical Research — Marseille, France (enrolling)
• Hospital Clínic de Barcelona (Dermatology service) — Barcelona, Spain (enrolling)

Full record on ClinicalTrials.gov

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