The Progress of Diabetes After Supaglutide Treatment in Type 2 Diabetes Patients

Recruiting now

Conditions studied: Type 2 Diabetes Mellitus

In brief

Glucagon like peptide-1 receptor agonist (GLP-1RA) can enhance insulin secretion and inhibit glucagon secretion in a glucose concentration dependent manner, delay gastric emptying, and reduce food intake through central appetite inhibition, thus achieving the effect of lowering glucose. Supaglutide Injection (YN-011, Diabegone®) has the characteristic of high affinity with GLP-1 receptors. Previous studies by Weng Jianping had shown that early use of short-term insulin fortification and oral medication (sulfonylureas and metformin) fortification therapy for newly diagnosed T2DM still resulted in clinical remission in about 50% of patients one year after discontinuation of medication, i.e. no hypoglycemic drugs were used, only diet and exercise therapy were maintained. At the same time, early fortification therapy can promote pancreatic islets β Cell repair. At present, there are few studies on the clinical remission rate of diabetes after GLP-1RA hypoglycemic treatment for one year. This study aims to discontinue the use of Supaglutide treatment after 52 or 28 weeks, and continue a one-year non pharmacological intervention observation to observe the clinical remission rate of diabetes, the changes in pancreatic islets β and α cell function, insulin resistance, body composition, and blood glucose fluctuations of patients who stopped using Supaglutide for 3 months and 1 year .

Key facts

Study ID

NCT06605287

Run by

Nanjing First Hospital, Nanjing Medical University

People needed

100

Starts

2023-03-13

Expected to finish

2025-12-31

Last updated by the study team

2024-09-20

Who can join

Age: 18 and older, up to 75. Sex: any. Healthy volunteers: not accepted.

You may qualify if…

• Complete a multicenter, randomized, double-blind, placebo-controlled clinical study on the efficacy of Supaglutide in T2DM patients with poor glucose control after dietary and exercise interventions (YN011-301);
• HbA1c ≤ 7.0%;
• The researchers determined that the patient's glucose control was stable based on the visit data of the subjects during the treatment with Supaglutide and the testing indicators of our hospital;
• The subjects agree to maintain scientific dietary and exercise habits throughout the entire research process, regularly conduct SMBG and keep records;
• Able to understand and willing to sign a written informed consent form and comply with the research protocol.

You may not qualify if…

• The researchers believe that the subjects have a disease state where they cannot complete the observation period follow-up;
• The researchers determined that there were situations in the subjects that affected the compliance of this study during the treatment with Supaglutide.

Where it is running

• Nanjing First Hospital, Nanjing Medical Univesity — Nanjing, China (enrolling)

Full record on ClinicalTrials.gov

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