Genomics and Microbiome Investigation in Cases of Recurrent Pregnancy Losses

Recruiting now

Conditions studied: Recurrent Pregnancy Loss(RPL)

In brief

Recurrent pregnancy losses (RPL) are characterized by the occurrence of more than one spontaneous pregnancy loss. It is caused by different known factors, but about half of the cases remain without an explanation. Efforts are being done in the scientific community to solve this cases. In this study, the investigators aim to investigate genetic factors that might predispose to RPL, as well as the influence of the uterine microbiota (microorganisms that normally live in the uterus of women).

Key facts

Study ID

NCT06604338

Run by

Hospital de Clinicas de Porto Alegre

People needed

20

Starts

2023-04-14

Expected to finish

2025-12-01

Last updated by the study team

2024-09-19

Who can join

Age: any. Sex: female. Healthy volunteers: not accepted.

You may qualify if…

• RPL group: history of at least two spontaneous pregnancy losses, regardless of whether they have living children, and whose etiology for the pregnancy losses was not determined by the care team\'s protocols;
• Control group: at least two full-term pregnancies and no history of difficulty getting pregnant, pregnancy loss or other infertility factors.

You may not qualify if…

• RPL group: less than two spontaneous pregnancy losses and those with a known cause for repeated pregnancy losses;
• Control group: N/A

Where it is running

• Hospital de Clínicas de Porto Alegre (HCPA) — Porto Alegre, Rio Grande do Sul, Brazil (enrolling)

Full record on ClinicalTrials.gov

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