A Study Evaluating the Safety, Tolerability, and Efficacy of EVO756 in Adults With Chronic Inducible Urticaria

Completed · Phase 2

Conditions studied: Chronic Inducible Urticaria

In brief

This phase 2a trial will evaluate the safety and efficacy of EVO756 in subjects with chronic inducible urticaria, including symptomatic dermographism and cold urticaria.

Key facts

Study ID

NCT06603220

Run by

Evommune, Inc.

People needed

30

Starts

2024-08-14

Expected to finish

2025-05-08

Last updated by the study team

2026-05-19

Who can join

Age: 18 and older, up to 65. Sex: any. Healthy volunteers: not accepted.

You may qualify if…

• Confirmed diagnosis of chronic inducible urticaria for at least 3 months.
• Positive response following provocation using the TempTest or FricTest at Screening and Day 1.

You may not qualify if…

• History of diseases other than chronic inducible urticaria or chronic spontaneous urticaria with urticaria or angioedema symptoms, such as urticarial vasculitis, erythema multiforme, cutaneous mastocytosis (urticaria pigmentosa), and hereditary or acquired angioedema.
• Concurrent use of certain medications, including antihistamines.
• Any clinically significant disease, or other skin disease or skin markings (e.g., extensive scarring, tattoos), that might confound the evaluation of safety or efficacy.

Where it is running

• Cahaba Dermatology & Skin Health Center, LLC — Birmingham, Alabama, United States
• California Allergy and Asthma Medical Group — Los Angeles, California, United States
• Integrative Skin Science and Research — Sacramento, California, United States
• West Dermatology Research Center — San Diego, California, United States
• Advanced Clinical Research Institute — Tampa, Florida, United States
• Aeroallergy Research Laboratories of Savannah, Inc. — Savannah, Georgia, United States
• Treasure Valley Medical Research — Boise, Idaho, United States
• Dawes Fretzin Clinical Research Group, LLC — Indianapolis, Indiana, United States
• Southern Indiana Clinical Trials — New Albany, Indiana, United States
• Indiana Clinical Trials Center, P.C. — Plainfield, Indiana, United States
• DelRicht Research — Baton Rouge, Louisiana, United States
• Chesapeake Clinical Research, Inc — White Marsh, Maryland, United States
• OptiSkin Medical — New York, New York, United States
• Red River Research Partners — Fargo, North Dakota, United States
• Bexley Dermatology Research — Bexley, Ohio, United States
• Allergy, Asthma, and Clinical Research Center — Oklahoma City, Oklahoma, United States
• Allergy and Clinical Immunology Associates — Pittsburgh, Pennsylvania, United States
• Austin Institute for Clinical Research — Pflugerville, Texas, United States

Full record on ClinicalTrials.gov

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