The Effect of Pre-Operative Cryoneurolysis on Post-Operative Narcotic Consumption in Patients Undergoing Autograft ACL Reconstruction

Recruiting now · Not applicable

Conditions studied: ACL Repair

In brief

The purpose of the research is to investigate the effect of preoperative Cryoneurolysis of the knee on postoperative pain management in patients undergoing autograft anterior cruciate ligament (ACL) reconstruction (a surgical procedure that makes a new ACL using the patient's own tendon). Cryoneurolysis is an approved process of applying extreme cold temperatures to targeted nerves in order to decrease or eliminate pain. . If you take part in the research, you will be randomly assigned (assigned by chance, like a flip of a coin) to Group A (standard care) or Group B (standard care plus Cryoneurolysis). Participants in both groups will undergo standard ACL reconstruction and receive standard preoperative and postoperative pain management. Participants in Group B only will also receive a standard treatment of Cryoneurolysis to their surgical knee within 7-10 days before their scheduled surgery. Participants in both groups (A \& B) will be asked to bring their remaining postoperative pain medication to their postoperative follow-up appointments for review by study personnel. Participants will also be asked to complete a survey about their knee activity, function and symptoms at these appointments. Your time in the study will last until the completion of the 12-week postoperative follow-up appointment.

Key facts

Study ID

NCT06603051

Run by

Virtua Health, Inc.

People needed

20

Starts

2024-08-28

Expected to finish

2027-10-01

Last updated by the study team

2026-05-12

Who can join

Age: 14 and older. Sex: any. Healthy volunteers: not accepted.

You may qualify if…

• - Patients aged 14 and over
• Patients who are patients within the PI's practice
• Patients who can speak and read English
• Patients undergoing autograft ACL reconstruction.
• Patients who are opioid naïve

You may not qualify if…

• - Under the age of 14
• Non-English speaking/reading patients
• Patients with Reynauds' syndrome
• Patients with skin disorders or hypo-vascularity
• Patients undergoing allograft ACL reconstruction.
• Patients who consistently use opioids preoperatively

Where it is running

• Virtua Orthopedics Burlington — Burlington, New Jersey, United States (enrolling)
• Virtua Orthopedics Cherry Hill — Cherry Hill, New Jersey, United States (enrolling)

Full record on ClinicalTrials.gov

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