Long-term Alterations of Host-microbiome Interactions and Cardiovascular and Respiratory Diseases Progression After Pneumonia
Recruiting now · Not applicable
Conditions studied: Hospital Acquired Pneumonia (HAP), Cardiovascular and Respiratory Disease
In brief
The HOMI-LUNG - HAP study is part of the HOMI-LUNG project, funded by the Horizon Europe program. The "HOMI-LUNG" project is an international, interdisciplinary project that aims to better understand the causal links between respiratory tract infections (i.e. pneumonia) and the progression of cardiovascular disease. More specifically, the project aims to quantify the burden of cardiovascular disease after pneumonia and assess patients; acceptability of long-term health alterations, as well as to define pneumonia endotypes with distinct pathobiological mechanisms associated with exacerbation of cardiovascular disease.
Key facts
- Study ID
- NCT06602934
- Run by
- Nantes University Hospital
- People needed
- 300
- Starts
- 2025-01-02
- Expected to finish
- 2029-01-01
- Last updated by the study team
- 2026-06-04
Who can join
Age: 18 and older, up to 80. Sex: any. Healthy volunteers: not accepted.
You may qualify if…
- Group A (patients with acute cardiac disease)
- Male or female
- Hospitalized for acute coronary syndrome for less than 7 days.
- Informed consent from the patient
- Person insured under a health insurance scheme
- Group B (patients with chronic cardiovascular disease)
- Male or female,
- Undergoing coronary artery by-pass surgery
- Hospitalized in intensive care unit for \> 12 hours
- Informed consent from the patient
- Person insured under a health insurance scheme
- Group C (patients at risk of CVRD without chronic cardiovascular disease)
- Male or female,
- Familial high levels of cholesterol or triglycerides
- With no personal history of CVRD, with a recent negative cardiac exercise test (last test inferior to 12 months)
- Follow-up for lipid abnormalities at high risk of CVRD events
- Informed consent from the patient
- Person insured under a health insurance scheme
- Group D (patients with HAP)
- Male or female
- With one or more risk factors for CVD among:
- Age ≥ 65 years old Smoking, Abnormal lipidic levels, High blood pressure, Obesity, Diabetes mellitus, Chronic kidney disease
- Cured from mechanically ventilated HAP during the current hospitalization
- Informed consent from the patient or relatives
- Person insured under a health insurance scheme
You may not qualify if…
- Groups A, B, C and D
- Age <80 years old
- Immunosuppression pre-existing to the index hospitalisation, defined as lymphopenia; 500 elements/mm3, haematologic cancer, aplasia, chemotherapy/radiotherapy for cancer within 3 months prior to the inclusion, or anti-graft rejection drug.
- Pregnant women, breastfeeding women.
- Adults under guardianship or trusteeship.
- Low probability of survival at day 28.
- o Groups A, B, C
- Community-acquired pneumonia or Hospital-acquired pneumonia within the last year.
Where it is running
- Nantes University Hospital — Nantes, France (enrolling)
- Angers University Hospital — Angers, France
- Rennes University Hospital — Rennes, France
- Rouen University Hospital — Rouen, France
- Toulouse University Hospital — Toulouse, France
Full record on ClinicalTrials.gov
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