" Study of the Benefit of Nebulized Amikacin in the Treatment of Gram-negative Bacillus Pneumonia Acquired During Mechanical Ventilation in Patients Receiving Extracorporeal Membrane Veno-arterial Oxygenation "

Starting soon · Phase 2

Conditions studied: Pneumonia, Bacterial, Extracorporeal Membrane Oxygenation

In brief

Pneumonia are the most frequent infectious complication in patients on Extracorporeal Membrane Oxygenation Veno-arterial (ECMO-VA), with a treatment failure rate of around 40%, even though antibiotic therapy is tailored to the germs identified. One hypothesis to explain this particularly high failure rate is the reduced pulmonary blood flow associated with ECMO offloading of the heart. Although there are no data to date on the pulmonary penetration of antibiotics in patients undergoing VA-ECMO, this phenomenon of pulmonary hypoperfusion could contribute to altering the alveolocapillary diffusion of antibiotics, thereby reducing their concentration in the pulmonary parenchyma. Our hypothesis is that amikacin nebulization could increase bacterial clearance and, ultimately, limit treatment failure or recurrence of gram-negative bacilli (GNB) pneumonia in patients undergoing VA-ECMO.

Key facts

Study ID: NCT06602557
Run by: Assistance Publique - Hôpitaux de Paris
People needed: 26
Starts: 2026-11-15
Expected to finish: 2028-05-20
Last updated by the study team: 2026-07-08

Who can join

Age: 18 and older. Sex: any. Healthy volunteers: not accepted.

You may qualify if…

Patient 18 years or older
Circulatory assistance by veno-arterial ECMO for at least 24 hours prior to documentation of pneumonia
Invasive mechanical ventilation
Diagnostic suspicion of pneumonia based on evocative criteria (presence of at least 2 of the following criteria): fever (superior to 38. 5°C), hypothermia (inferior to 36.0°C), hyperleukocytosis (superior to 11 × 10\^9 l-1) or leukopenia (inferior to 4 × 10\^9 l-1), purulent tracheobronchial secretions, altered oxygenation with need to increase FiO2 on ECMO or ventilator for the same SaO2 or PaO2 target, new or persistent pulmonary infiltrate(s) on chest x-ray in bed, or image suggestive of pneumonia on chest CT, or consolidation of appearance suggestive of an infectious origin on pulmonary ultrasound.
And microbiological confirmation of Gram-negative ventilator-associated pneumonia by quantitative culture on bronchoalveolar lavage (BAL, significance threshold superior to 10\^4 CFU/ml) or protected distal sampling (PDP, significance threshold superior to 10\^3 CFU/ml).
Probabilistic antibiotic therapy with piperacillin - tazobactam
Informed consent obtained from the patient or trusted support person if unable to consent at the time of inclusion, or inclusion procedure in emergency situations.
Patient affiliated to social security (excluding AME)

You may not qualify if…

Known allergy to amikacin or another aminoglycoside or to an auxiliary drug or to any of their excipients.
Contraindication to the administration of amikacin or its excipients listed in the summary of product characteristics.
Contraindication to the administration of an auxiliary drug or to one of its excipients listed in the summary of product characteristics.
Contraindications to nebulization
Intravenous antibiotic therapy started more than 72 hours before randomization
Probabilistic venous antibiotic therapy other than piperacillin - tazobactam
Administration of inhaled antibiotics within 7 days prior to inclusion
Positive pregnancy test for women of childbearing potential
Presence of HIV infection with CD4 count inferior to 200 cells/mm3 or fungal lung infection or pulmonary abscess or empyema
Presence of renal insufficiency with creatinine clearance inferior to 15 ml/min, with the exception of patients receiving continuous renal purification or daily hemodialysis sessions as part of their intensive care unit management.
Patent moribund (SAPS II superior to 75) or high probability of death within 48 hours
Patient under legal protection (curatorship, guardianship or safeguard of justice)
Participating in another interventional clinical trial or within the exclusion period at the end of a previous study.

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