Efficacy of Steroid Injection in Patients With Bifid Median Nerve Diagnosed Carpal Tunnel Syndrome

Recruiting now · Not applicable

Conditions studied: Carpal Tunnel Syndrome

In brief

Various median nerve anatomical variations have been reported in the literature.One of these is the bifid median nerve.Due to its relatively higher cross-sectional area, it can facilitate compression of the median nerve in the carpal tunnel.Therefore, bifid median nerve is relatively common in patients with CTS.Some studies have shown that the bifid median nerve has an effect on surgical failure in the treatment of carpal tunnel syndrome.Apart from surgical treatment, perineural injection with corticosteroids is a treatment method that has been used for a long time in the treatment of mild and moderate carpal tunnel syndrome.It is controversial whether bifid median nerve has a negative effect on treatment effectiveness.When looking at the literature, there is no previous study on this subject.With the introduction of ultrasound into our daily practice, the frequency of ultrasound-guided perineural injections has increased.Ultrasound allowed us to see variations in the median nerve before injection.The aim of the study is to compare the effectiveness of steroid injection in patients with CTS with bifid median nerve and patients with CTS with non-variant median nerve.It is also to investigate whether this anatomical variation has a negative effect on the treatment.

Key facts

Study ID

NCT06599086

Run by

Yunus Burak Bayır

People needed

40

Starts

2024-09-15

Expected to finish

2025-09-14

Last updated by the study team

2025-05-30

Who can join

Age: 18 and older, up to 65. Sex: any. Healthy volunteers: not accepted.

You may qualify if…

• Being between the ages of 18-65
• Being clinically diagnosed with Carpal Tunnel Syndrome
• Confirmation of mild and moderate Carpal Tunnel Syndrome diagnosis with EMG
• Diagnosis of bifid median nerve after ultrasound evaluation, No variation was detected for the control group either.
• Having typical Carpal Tunnel Syndrome symptoms for at least 3 months

You may not qualify if…

• History of polyneuropathy, brachial plexopathy, thoracic outlet syndrome, or wrist surgery
• History of Inflammatory arthritis, hypothyroidism, pregnancy,rheumatological disorders or heart battery
• current warfarin use, Prior steroid injection for CTS, trauma or neoplasm at the injection site, hypersensitivity to corticosteroids or skin infection at the injection site
• other median nerve variations and presence of persistent median artery.

Where it is running

• Etlik City Hospital — Ankara, Ankara, Turkey (Türkiye) (enrolling)

Full record on ClinicalTrials.gov

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