Insulin Resistance and Coronary Microvascular Dysfunction in Patients with Myocardial Ischemia and Non-obstructive Coronary Artery Disease

Recruiting now · Not applicable

Conditions studied: Coronary Microvascular Dysfunction, Coronary Microvascular Disease, Insulin Resistance

In brief

The goal of this prospective study is to assess the correlation between coronary microvascular disfunction and insulin resistance in patients with INOCA. Patients with ANOCA and without diabetes will undergo invasive coronary microvascular assessment through coronary angiography and insulin resistance assessment through hyperinsulinemic-euglycemic clamp test. Patients enrolled in the study will be followed for a period of 2 years to monitor their clinical status.

Key facts

Study ID

NCT06597851

Run by

Azienda Ospedaliera Universitaria Integrata Verona

People needed

40

Starts

2024-06-24

Expected to finish

2026-06-30

Last updated by the study team

2024-09-19

Who can join

Age: 18 and older. Sex: any. Healthy volunteers: not accepted.

You may qualify if…

• Aged over 18 years.
• Cardiac chest pain with evidence of myocardial ischemia at noninvasive myocardial stress imaging and clinical indication to diagnostic coronary angiography
• Willing and able to give informed consent for participation in the study

You may not qualify if…

• Obstructive CAD (defined as more than 70% luminal stenosis and/or FFR ≤0.80 in 1 or more epicardial vessels).
• History of previous myocardial infarction, percutaneous revascularization or coronary-aortic bypass graft (CABG) surgery.
• Diagnosis of type II diabetes.
• BMI ≥ 35 kg/m2.
• Stage IV and V of chronic kidney disease (eGFR ≤ 30 ml/min, estimated through CKD - EPI Creatinine Equation).
• Allergy or other contraindication to iodinated contrast and/or gadolinium and/or adenosine.
• Chronic resting O2 saturation ≤ 85%.
• Pregnancy or suspected pregnancy.

Where it is running

• Azienda Ospedaliera Universitaria di Verona — Verona, VR, Italy (enrolling)

Full record on ClinicalTrials.gov

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