Cardiac Assessment and Takotsubo-stunning Among COPD-exacerbations In-Hospital

Recruiting now

Conditions studied: Chronic Obstructive Pulmonary Disease, Takotsubo Cardiomyopathy, Acute Heart Failure

In brief

The goal of this prospective observational study is to investigate to what extent acute exacerbation of chronic obstructive pulmonary disease (AE-COPD) triggers Takotsubo-stunning, and how this affects the outcome for these patients. The main questions it aims to answer are: 1. What is cumulative incidence of Takotsubo-stunning in patients hospitalized for AE-COPD at Sahlgrenska University Hospital/S (Gothenburg, Sweden)? 2. Among patients hospitalized for AE-COPD at Sahlgrenska University Hospital/S, what is the risk of in-hospital clinical manifestations of acute heart failure in patients with Takotsubo-stunning compared to those without?

Key facts

Study ID

NCT06597331

Run by

Sahlgrenska University Hospital

People needed

200

Starts

2024-09-23

Expected to finish

2027-09-01

Last updated by the study team

2025-05-14

Who can join

Age: 18 and older. Sex: any. Healthy volunteers: not accepted.

You may qualify if…

• Adult patients (≥ 18 years old) admitted to hospital ward for AE-COPD
• Inclusion within 72 hours of admission,
• Written informed consent

You may not qualify if…

• Prior acute myocardial infarction or known pre-existing persistent regional wall motion abnormality or left ventricular dysfunction (left ventricular ejection fraction [LVEF] <50%)
• Expected inability to comply with the protocol (e.g. dementia)

Where it is running

• Department of Emergency Medicine and Geriatrics, Sahlgrenska University Hospital/S — Gothenburg, Region Västra Götaland, Sweden (enrolling)

Full record on ClinicalTrials.gov

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