Loss of Y Chromosome in Aortic Stenosis

Recruiting now

Conditions studied: Aortic Stenosis

In brief

The most common heart valve disease in humans is aortic stenosis which is a critical narrowing of the valve through which the heart has to pump blood to the rest of the body. This condition occurs in 2-3% of adults over 65 years of age and when it progresses to a severe stage leads to heart failure and need for valve replacement procedures (including surgery and catheter-based replacement). Aortic stenosis has a strong male predominance. The purpose of this study is to evaluate whether loss of Y-chromosome from circulating blood cells in males, which has been associated with TGF-beta-related fibrosis of other organs, is associated with the development of aortic stenosis.

Key facts

Study ID

NCT06595407

Run by

University of Virginia

People needed

200

Starts

2024-08-15

Expected to finish

2026-06-01

Last updated by the study team

2024-09-19

Who can join

Age: 40 and older. Sex: male. Healthy volunteers: accepted.

You may qualify if…

• Aortic stenosis (valve area \<1.5cm2)

You may not qualify if…

• Bicuspid aortic valve
• History of radiation to chest
• Inflammatory (autoimmune, rheumatologic) disease associated with aortic stenosis
• Active cancer

Where it is running

• University of Virginia — Charlottesville, Virginia, United States (enrolling)

Full record on ClinicalTrials.gov

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