Investigating the Impact of Duration and Amount of Light on the Circadian System Response - Aim 3

Completed · Not applicable

Conditions studied: Alzheimer's Disease, Mild Cognitive Impairment

In brief

Investigate the long-term impact of amount and duration of Tailored Lighting Intervention (TLI) obtained from Aims 1 and 2 on sleep, cognition, circadian marker, mood, and behavior in AD/ADRD patients. For this single-arm, randomized, placebo-controlled study, the researchers plan to recruit 100 participants who will experience either the active TLI or the placebo for 6 months.

Key facts

Study ID

NCT06595030

Run by

Icahn School of Medicine at Mount Sinai

People needed

101

Starts

2024-12-03

Expected to finish

2026-01-31

Last updated by the study team

2026-02-17

Who can join

Age: 55 and older. Sex: any. Healthy volunteers: not accepted.

You may qualify if…

• Diagnosis of Alzheimer's disease or related dementia with a Montreal Cognitive Assessment score <25
• Sleep disturbance with a Pittsburgh Sleep Quality Index score ≥5

You may not qualify if…

• Extensive brain vascular disease, traumatic brain injury, multiple sclerosis, Parkinson's Disease
• Obstructing cataracts
• Severe macular degeneration
• Use of sleep medication
• Use of oral melatonin
• untreated moderate to severe sleep apnea
• Severe restless leg syndrome - Blindness

Where it is running

• Icahn School of Medicine at Mount Sinai — Menands, New York, United States
• Icahn School of Medicine at Mount Sinai — New York, New York, United States

Full record on ClinicalTrials.gov

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