Study of the Nasal Intracellular Reservoir of Staphylococcus Aureus in Patients With S. Aureus Bacteremia

Recruiting now

Conditions studied: Bacteria Infection Mechanism

In brief

Staphylococcus aureus bacteremia is a serious infection associated with a high mortality rate (with or without associated infective endocarditis (IE)), long hospital stays and multiple complications, due to the terrain in which it occurs and its secondary localization. They may be community-acquired or healthcare-associated infections. Being a carrier of S. aureus is a known risk factor for S. aureus bacteremia. Although several mucosal sites of carriage have been described, screening for carriage is most often carried out at the nasal level, both for reasons of simplicity and because it is the predominant site of carriage of this bacterium. However, S. aureus carriage is a frequent occurrence, affecting around 1/3 of the general population.

Key facts

Study ID

NCT06594250

Run by

Centre Hospitalier Universitaire de Saint Etienne

People needed

405

Starts

2024-09-02

Expected to finish

2025-11-01

Last updated by the study team

2024-09-19

Who can join

Age: 18 and older. Sex: any. Healthy volunteers: not accepted.

You may qualify if…

• Bacteremia
• Patient affiliated or entitled to a social security plan
• Patient who has signed a consent form to participate in the study.

You may not qualify if…

• Antibiotic therapy in place for more than 5 days at the time of inclusion
• Nasal decolonization of S. aureus within 12 months
• Pregnant or breast-feeding women
• Patients under guardianship
• Polymicrobial bacteremia including S. aureus

Where it is running

• Centre Hospitalier Universitaire de St Etienne — Saint-Etienne, France (enrolling)

Full record on ClinicalTrials.gov

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