Study of Natriuretic Peptide Receptor 1 (NPR1) Antagonist in Adult Patients With Postural Orthostatic Tachycardia Syndrome (POTS)
Completed · Phase 2 · Has a placebo group
Conditions studied: Postural Orthostatic Tachycardia Syndrome (POTS)
In brief
This study is researching an experimental drug called REGN7544 (called "study drug"). The study is focused on participants with POTS. The aim of the study is to see how safe, tolerable, and effective the study drug is. The study is looking at several other research questions, including: * How the study drug changes heart rate and blood pressure in participants with POTS * What side effects may happen from taking the study drug * How much study drug is in the blood at different times * Whether the body makes antibodies against the study drug (which could make the study drug less effective or could lead to side effects) * How the study drug affects symptoms associated with POTS
Key facts
- Study ID
- NCT06593600
- Run by
- Regeneron Pharmaceuticals
- People needed
- 82
- Starts
- 2024-11-13
- Expected to finish
- 2026-07-08
- Last updated by the study team
- 2026-07-21
Who can join
Age: 18 and older, up to 55. Sex: any. Healthy volunteers: not accepted.
Where it is running
- Mercy Gilbert Medical Center — Gilbert, Arizona, United States
- North County Neurology Associates — Carlsbad, California, United States
- Stanford University — Palo Alto, California, United States
- Southern California Heart Specialists — Pasadena, California, United States
- Yale University — New Haven, Connecticut, United States
- Innovative Research of West Florida, Inc. — Clearwater, Florida, United States
- Indiana University Health Neuroscience Center — Indianapolis, Indiana, United States
- Beth Israel Deaconess Medical Center — Boston, Massachusetts, United States
- Mayo Clinic — Rochester, Minnesota, United States
- Saint Luke's MidAmerica Heart Institute — Kansas City, Missouri, United States
- New York University Langone — New York, New York, United States
- University of Oklahoma Health Sciences Center — Oklahoma City, Oklahoma, United States
- Vanderbilt University Medical Center — Nashville, Tennessee, United States
- University of Texas Southwestern — Dallas, Texas, United States
- University of Utah — Salt Lake City, Utah, United States
- University of Calgary — Calgary, Alberta, Canada
Full record on ClinicalTrials.gov
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