PFAS Exposure and Immune Response to Vaccination in Adults

Completed · Phase 4

Conditions studied: Innate Inflammatory Response, Vaccination, Diphtheria, Tetanus, Environmental Exposure, Vaccine, Antibodies, Adult, Immunity, Pollution; Exposure

In brief

This clinical trial aims to investigate how exposure to Perfluorononanoic acid (PFNA), a type of per- and polyfluoroalkyl substance (PFAS), affects the immune response to the standard tetanus and diphtheria (Td) vaccine. The study focuses on participants from a community with known prior PFNA exposure through contaminated drinking water. The main question it aims to answer is: * Does exposure to PFNA weaken the body's initial immune response, leading to lower levels of protective antibodies after vaccination? Participants will: * Receive Tetanus and Diphtheria (Td) booster vaccination * Visit the study office 7 times over a 30-day period * Have blood and saliva collected at each study visit

Key facts

Study ID

NCT06588530

Run by

Rutgers, The State University of New Jersey

People needed

20

Starts

2024-11-04

Expected to finish

2025-01-08

Last updated by the study team

2025-12-30

Who can join

Age: 18 and older, up to 89. Sex: any. Healthy volunteers: accepted.

You may qualify if…

• Participated in the Paulsboro PFAS Health Study
• Provided a blood sample for the Paulsboro PFAS Health Study
• Weigh at least 110 pounds

You may not qualify if…

• Currently Pregnant
• History of difficult blood draws
• History of adverse reaction to prior vaccinations
• Currently taking immune suppressants
• Recent dental surgery or dental procedure within 4 weeks of starting study
• Had a Td booster in the past 10 years

Where it is running

• EOHSI Paulsboro Office — Paulsboro, New Jersey, United States

Full record on ClinicalTrials.gov

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