Corticosteroid Effect on Achalasia Variant EGJOO

Running, not enrolling · Early Phase 1

Conditions studied: Esophagogastric Junction Outflow Obstruction

In brief

EGJOO is a disorder in which the muscles of the esophagus (swallowing tube) do not function in a coordinated fashion so that swallowed material does not pass easily into the stomach. EGJOO often causes symptoms of swallowing difficulties and chest pain. The cause of EGJOO and its optimal treatment are not clear. The investigators research team suspects that EGJOO might be caused by an allergy that involves the esophagus, and that treatment with medications called corticosteroids might improve function of the esophageal muscles. The purpose of this study is to learn how corticosteroid therapy affects the muscles of the esophagus in patients suffering with EGJOO.

Key facts

Study ID: NCT06588348
Run by: Baylor Research Institute
People needed: 12
Starts: 2022-07-26
Expected to finish: 2026-11-01
Last updated by the study team: 2026-01-28

Who can join

Age: 18 and older. Sex: any. Healthy volunteers: not accepted.

You may not qualify if…

History of prior foregut surgery
History of esophageal botulinum toxin injection within 6 months of study enrollment
Presence of hiatal hernia > 2 centimeters
Presence of esophageal mass
Obstructing esophageal stricture or ring on endoscopy
Reflux esophagitis (LA Grades B-D)
Subjects on current immunosuppression or immune modulating therapy
Chronic opioid use
Previously diagnosed extrinsic compression of the gastroesophageal junction
Concomitant Eosinophilic Esophagitis with uncontrolled mucosal disease who have not tried at least one standard therapy
Contraindication to the use of oral corticosteroids
History and/or current diagnosis of Diabetes

Where it is running

Baylor University Medical Center — Dallas, Texas, United States

Full record on ClinicalTrials.gov

Trial information comes from ClinicalTrials.gov and is refreshed daily. TrialsForMe does not provide medical care and does not run the studies it lists.