Single and Multiple Ascending Dose Study of AMG 513 in Participants With Obesity
Recruiting now · Phase 1 · Has a placebo group
Conditions studied: Cardiometabolic Disease
In brief
The primary objective of this study is to assess the safety and tolerability of AMG 513 after single and multiple doses.
Key facts
- Study ID
- NCT06585462
- Run by
- Amgen
- People needed
- 80
- Starts
- 2024-09-09
- Expected to finish
- 2026-10-01
- Last updated by the study team
- 2026-06-22
Who can join
Age: 18 and older, up to 65. Sex: any. Healthy volunteers: accepted.
You may qualify if…
- Participants in the study will be males and females 18 to 65 years of age at the time of signing the informed consent with a body mass index (BMI) of 30.0 kg/m\^2 to 40.0 kg/m\^2 for Part A and BMI of 27.0 kg/m\^2 to 40.0 kg/m\^2 for Part B.
- Females enrolled must be of non-childbearing potential.
You may not qualify if…
- History and/or clinical evidence of diabetes mellitus, including hemoglobin A1c ≥ 6.5% and/or a fasting glucose of ≥ 126 mg/dL (7 mmol/L) at screening.
- Triglycerides ≥ 5.65 mmol/L (i.e., 500 mg/dL) at screening.
Where it is running
- Anaheim Clinical Trials — Anaheim, California, United States (enrolling)
- Orange County Research Center — Lake Forest, California, United States (enrolling)
- Fomat Medical Research — Oxnard, California, United States (enrolling)
- Translational Clinical Research LLC — Aventura, Florida, United States (enrolling)
- Clinical Neuroscience Solutions - Jacksonville — Jacksonville, Florida, United States (enrolling)
- New Horizon Research Center — Miami, Florida, United States (enrolling)
- Clinical Pharmacology of Miami, LLC — Miami, Florida, United States (enrolling)
- Rophe Adult and Pediatric Medicine/Sky Clinical Research Network Group — Union City, Georgia, United States (enrolling)
- Lillestol Research LLC — Fargo, North Dakota, United States (enrolling)
- Pinnacle Clinical Research — Austin, Texas, United States (enrolling)
Full record on ClinicalTrials.gov
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