A Study of Orforglipron for the Maintenance of Body Weight Reduction in Participants Who Have Obesity or Overweight With Weight-Related Comorbidities (ATTAIN-MAINTAIN)
Completed · Phase 3 · Has a placebo group
Conditions studied: Obesity, Overweight
In brief
The main purpose of this study is to evaluate the efficacy and safety of orforglipron on maintenance of body weight reduction in participants who previously completed treatment with injectable tirzepatide (Zepbound) or injectable semaglutide (Wegovy) in the SURMOUNT-5 trial (NCT05822830).
Key facts
- Study ID
- NCT06584916
- Run by
- Eli Lilly and Company
- People needed
- 376
- Starts
- 2024-09-13
- Expected to finish
- 2025-11-21
- Last updated by the study team
- 2026-06-04
Who can join
Age: 18 and older. Sex: any. Healthy volunteers: not accepted.
You may qualify if…
- Have completed the SURMOUNT-5 study (NCT05822830; a trial of injectable tirzepatide [Zepbound] versus injectable semaglutide [Wegovy]) on study treatment
You may not qualify if…
- Have Type 1 Diabetes, Type 2 Diabetes, or any other types of diabetes, history of ketoacidosis, or hyperosmolar state/coma
- Have a prior or planned surgical treatment for obesity
- Have acute or chronic hepatitis
- Have a history of acute or chronic pancreatitis
Where it is running
- Cahaba Research — Birmingham, Alabama, United States
- Cahaba Research - Pelham — Pelham, Alabama, United States
- Southern California Dermatology, Inc. — Santa Ana, California, United States
- Encompass Clinical Research — Spring Valley, California, United States
- University Clinical Investigators, Inc. — Tustin, California, United States
- New Horizon Research Center — Miami, Florida, United States
- Rophe Adult and Pediatric Medicine/SKYCRNG — Union City, Georgia, United States
- Rocky Mountain Clinical Research — Idaho Falls, Idaho, United States
- Iowa Diabetes and Endocrinology Research Center — West Des Moines, Iowa, United States
- L-MARC Research Center — Louisville, Kentucky, United States
- Arcturus Healthcare , PLC, Troy Internal Medicine Research Division — Troy, Michigan, United States
- Prime Health and Wellness/SKYCRNG — Fayette, Mississippi, United States
- StudyMetrix Research — City of Saint Peters, Missouri, United States
- Palm Research Center Tenaya — Las Vegas, Nevada, United States
- Palm Research Center Sunset — Las Vegas, Nevada, United States
- Weill Cornell Medical College — New York, New York, United States
- PharmQuest Life Sciences, LLC — Greensboro, North Carolina, United States
- Lillestol Research — Fargo, North Dakota, United States
- Alliance for Multispecialty Research, LLC — Norman, Oklahoma, United States
- Tribe Clinical Research, LLC — Greenville, South Carolina, United States
- WR-Clinsearch, LLC — Chattanooga, Tennessee, United States
- The University of Texas Health Science Center at Houston — Bellaire, Texas, United States
- Velocity Clinical Research, Dallas — Dallas, Texas, United States
- North Texas Endocrine Center — Dallas, Texas, United States
- Biopharma Informatic, LLC — Houston, Texas, United States
Full record on ClinicalTrials.gov
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