The Effect of Anti-inflammatory Cryoagent on the Level of Postoperative Pain in Patients With Symptomatic Irreversible Pulpitis and Apical Periodontitis.

Starting soon · Phase 2

Conditions studied: Postoperative Pain

In brief

* The aim of this study is comparative between: 1. Intra-radicular cryotherapy using cold anti-inflammatory {ketorolac tromethamine at 2-5C}. 2. Intra-radicular final flush anti-inflammatory {ketorolac tromethamine at room temperature}. * In terms of: C. Level of post-operative pain {POP} using a visual analog scale {VAS}. D. Level of substance P in periapical fluid will be analyzed by enzyme-linked immunosorbent assay (ELISA) kit. Outcomes : * Primary outcomes: Level of Post-operative pain. * Secondary outcomes: Level of substance P expression

Key facts

Study ID

NCT06584188

Run by

Ain Shams University

People needed

60

Starts

2026-04-11

Expected to finish

2026-04-30

Last updated by the study team

2026-04-15

Who can join

Age: 18 and older, up to 40. Sex: any. Healthy volunteers: accepted.

You may qualify if…

• Patients that will be diagnosed with symptomatic irreversible pulpitis and apical periodontitis.
• Patient age ranging from 18-40 years.
• Males or females.
• Lower premolars.
• Medically free patients.
• Teeth with mature apex.
• Teeth without any type of root resorption.

You may not qualify if…

• Patients with other pulpal diagnosis.
• Medically compromised patients.
• Vulnerable group; pregnant females, mentally ill, etc...
• Patients taking analgesics or anti-inflammatory drugs.
• Teeth with open apex.

Where it is running

• Faculty of Dentistry, Ain Shams University — Cairo, Egypt

Full record on ClinicalTrials.gov

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