Black Rice Consumption on Cognitive Function, Inflammation and Microvascular Function in Older Adults

Recruiting now · Not applicable

Conditions studied: Older Adults

In brief

Cognitive (brain) function, especially memory, gradually declines during ageing, which may in part be caused by an increase in systemic inflammation as well as a reduction in vascular functions and cerebral blood flow. Blood inflammatory mediators such as c-reactive protein (CRP) and interleukin-6 (IL-6) found to be significantly higher among people over 65 years compared to younger age groups. Anthocyanins is water-soluble compounds giving blue, purple and red colours in fruits and vegetables. Anthocyanins have been demonstrated to improve cognitive function, inhibit inflammation, and protect cardiovascular health. Black rice contains high amounts of anthocyanins mainly cyanidin 3-glucoside and peonidin 3-glucoside as well as various nutritional compounds such as carbohydrate, vitamin B, vitamin E and fibre. Previous studies reported health benefits of black rice, including anti-inflammation, antioxidative stress, anti-diabetes, and improved cognitive function. However, the effect of black rice consumption on cognitive function related to inflammation has not been studied in humans. Therefore, this study aims evaluate the acute \& short-term effects of black rice consumption on the cognitive function, inflammation, and vascular function in older adults aged 50-80 years. The primary and secondary research questions of this study will address: 1. Do the acute and short-term anthocyanin-rich black rice intakes improve cognitive function in older adults aged 50-80 years? 2. Do the acute and short-term anthocyanin-rich black rice intakes modulate inflammatory status and microvascular function in older adults aged 50-80 years?

Key facts

Study ID

NCT06583785

Run by

University of Reading

People needed

24

Starts

2023-12-05

Expected to finish

2024-12-31

Last updated by the study team

2024-09-04

Who can join

Age: 50 and older, up to 80. Sex: any. Healthy volunteers: accepted.

You may qualify if…

• Aged 50-80 years
• General healthy status
• Body Mass Index (BMI)18.5-35 kg/m2

You may not qualify if…

• Taking anti-inflammatory drugs (e.g., aspirin, warfarin, ibuprofen)
• Having sign of infections or acute inflammation (e.g., fever, chills, sore throat, nasal congestion, moderate-severe pain, swelling-redness)
• Received antibiotics within the past 3 months
• Taking dietary supplements (e.g., vitamins, minerals) at high doses (e.g., more than 200% of the UK's reference nutrient intakes)
• Taking hormone replacement therapy, if you are menopausal
• Had major surgery (head, heart, chest, abdomen) within the past 6 months.
• Having plan to start to a restricted diet/ changing dietary pattern or lose weight.
• Diagnosed with neurodegenerative diseases (e.g., Dementia, Alzheimer's, Parkinson's, current stroke)
• Diagnosed with psychotic disorders (e.g., schizophrenia, bipolar depression, eating disorder)
• Diagnosed with cardiovascular disease, diabetes, hyperlipidemia, hypertension (blood pressure>140/90 mmHg), active cancer, liver, or kidney diseases.
• Taking medication to lower blood fats (e.g., statins, fibrates) or to stabilise blood glucose (e.g., acarbose, metformin or sulfonylureas) or lower blood pressure.
• Unable to complete the cognitive function tasks for any reason (i.e., visual impairments, hearing loss)
• If you have a peacemaker
• If you have bleeding disorders or blood related diseases (anaemia, thalassemia, thrombosis, embolism)
• Heavy smoker
• Heavy alcohol drinking (> 14 units/week) or a history of alcohol/substance abuse
• Allergies, hypersensitivity, or food intolerances (rice, eggs, soy sauce, vegetable oil)

Where it is running

• Hugh Sinclair Unit of Human Nutrition — Reading, UK, United Kingdom (enrolling)
• Hugh Sinclair Unit of Human Nutrition, Department of Food and Nutritional Sciences, University of Reading — Reading, United Kingdom (enrolling)

Full record on ClinicalTrials.gov

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