Lynch Syndrome Integrative Epidemiology and Genetics

Recruiting now

Conditions studied: Lynch Syndrome

In brief

The vision of the "Lynch syndrome INtegrative Epidemiology And GEnetics" (LINEAGE) Consortium is to collaboratively improve the lives and longevity of individuals and families with Lynch syndrome. The mission of the LINEAGE Consortium is to collaboratively improve Lynch syndrome care through high-quality research. This consortium will provide intellectual and infrastructure support to facilitate development of research questions, collection of standardized data and biospecimens, support of grant applications, and generation of collaborative manuscripts. Our aims are to: I. Establish a prospective cohort of individuals with Lynch syndrome II. Collect standardized longitudinal clinical and biosample data to elucidate Lynch Syndrome epidemiology and gene-host interactions III. Promote intervention trials to improve cancer prevention and early detection in Lynch Syndrome

Key facts

Study ID

NCT06582914

Run by

University of Colorado, Denver

People needed

5000

Starts

2024-10-01

Expected to finish

2054-12-31

Last updated by the study team

2025-01-15

Who can join

Age: 18 and older. Sex: any. Healthy volunteers: not accepted.

You may qualify if…

• • Adults age over 18 years
• Eligible patients must have at least one variant of uncertain significance (VUS), pathogenic or likely pathogenic variant (PV/LPV) in MLH1, MSH2, MSH6, PMS2, or EPCAM, which will be confirmed by genetic testing results (obtained as part of routine care) and a review of the variant in ClinVar (https://www.ncbi.nlm.nih.gov/clinvar/).
• Individuals who are an obligate carrier of a LS PV/LPV that is confirmed in the family.

You may not qualify if…

• Age under 18

Where it is running

• University of Colorado — Aurora, Colorado, United States (enrolling)
• University of Chicago — Chicago, Illinois, United States

Full record on ClinicalTrials.gov

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