Lidocaine Infusion Treatment for Subarachnoid Hemorrhage Headaches

Recruiting now

Conditions studied: Subarachnoid; Hemorrhage, Nontraumatic, Headache

In brief

The goal of this observational study is to evaluate intravenous lidocaine efficacy and safety in treating headache following non-traumatic subarachnoid hemorrhage. Through this prospective analysis, the investigators hope to: 1. show that intravenous lidocaine infusion causes a clinically significant reduction in pain scores in patients with moderate/severe headache pain following non-traumatic subarachnoid hemorrhage; 2. show that intravenous lidocaine infusion is safe in treating headache following non-traumatic subarachnoid hemorrhage; 3. and report vasospasm prevalence in the cohort. Participants will receive lidocaine infusion as treatment for non-traumatic subarachnoid hemorrhage headache and provide pain scores (on a numeric pain scale) every two hours the patients are awake for a maximum of seven days. Monitoring for vasospasm will occur as part of the patients regular medical care.

Key facts

Study ID

NCT06582810

Run by

University of Kansas Medical Center

People needed

20

Starts

2025-01-31

Expected to finish

2028-07-01

Last updated by the study team

2026-07-10

Who can join

Age: 18 and older. Sex: any. Healthy volunteers: not accepted.

You may qualify if…

• Patients > 18 years;
• Have a favorable neurological status defined as Hunt and Hess score ≤ 3 (as it accounts for patient awareness);
• Can communicate numeric pain scores;
• Are diagnosed with non-traumatic subarachnoid hemorrhage

You may not qualify if…

• The patient is diagnosed with traumatic subarachnoid hemorrhage;
• If the patient is < 18 years of age;
• If numeric pain scores could not be captured for > 3 days of hospitalization;
• If the patient had a prior aneurysm;
• Chronic pain not associated with non-traumatic subarachnoid hemorrhage diagnosis;
• A disability before the stroke (> 2 on modified Rankin Scale score);
• A Hunt and Hess score > 3;
• Contraindications to lidocaine (significant cardiac disease, arrhythmia, seizures, previous allergic reaction to lidocaine

Where it is running

• Ascension Via Christi St. Francis — Wichita, Kansas, United States (enrolling)

Full record on ClinicalTrials.gov

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