Is the 3D-PANC MSP Model Superior to CT for Assessing Response to Neoadjuvant Treatment in PCA Patients?

Recruiting now

Conditions studied: Adenocarcinoma of the Pancreas

In brief

Prospective multicenter study in which all patients with borderline or locally advanced pancreatic adenocarcioma undergoing neoadjuvant chemotherapy and surgical exploration with curative intent will be included for one year. Preoperative images by traditional CT and 3D-MSP technology will be evaluated, comparing the accuracy variables (sensitivity, specificity, predictive values, area under the curve, concordance index) of both techniques with the gold standard (results of surgery and histopathological analysis).

Key facts

Study ID: NCT06582342
Run by: Fundación para la Investigación del Hospital Clínico de Valencia
People needed: 70
Starts: 2024-03-21
Expected to finish: 2025-12-30
Last updated by the study team: 2025-08-06

Who can join

Age: 18 and older. Sex: any. Healthy volunteers: not accepted.

You may qualify if…

Patients with a diagnosis of borderline or locally advanced PAC of the head of the pancreas, as defined by the National Comprehensive Cancer Network (NCCN), who have received neoadjuvant treatment and who undergo surgical exploration with resective intent.

You may not qualify if…

Patients younger than 18 years of age.
Patients under 18 years of age.
Disease progression during neoadjuvant treatment.
No preoperative CT scan.
Refusal to participate in the study.

Where it is running

Hospital General de Alicante — Alicante, Spain (enrolling)
Hospital Universitario de Badajoz — Badajoz, Spain (enrolling)
Hospital del Mar (Barcelona) — Barcelona, Spain (enrolling)
Hospital Clínic de Barcelona — Barcelona, Spain (enrolling)
Hospital de Bellvitge — Barcelona, Spain (enrolling)
Hospital German Trias y Puyol — Barcelona, Spain (enrolling)
Hospital Nuestra señora de la Candelaria — Candelaria, Spain (enrolling)
Hospital General de Castellón — Castellon, Spain (enrolling)
Hospital Carlos Haya — Málaga, Spain (enrolling)
Hospital Virgen de la Victoria — Málaga, Spain (enrolling)
Hospital Virgen de la Arrixaca — Murcia, Spain (enrolling)
Hospital Son Espases Palma de Mallorca — Palma de Mallorca, Spain (enrolling)
Hospital Virgen del Rocío — Seville, Spain (enrolling)
Hospital Juan XXIII Tarragona — Tarragona, Spain (enrolling)
Hospital Clínico Universitario de Valencia — Valencia, Spain (enrolling)
Hospital Dr Peset — Valencia, Spain (enrolling)
Hospital La Fe — Valencia, Spain (enrolling)

Full record on ClinicalTrials.gov

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